Ian Douglas Agranat

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The tumorigenic activities of benzo[a]pyrene (BP) and 6-fluorobenzo[a]pyrene (6-F-BP) were compared to determine whether an unsubstituted 6-position is important for the carcinogenic effect of BP. Highly purified samples of 6-F-BP and BP had similar activities for the induction of lung adenomas in Swiss Webster mice treated before weaning. The 6-fluoro(More)
The effect of the plant diterpenes, phorbol derivatives and mezerein, on differentiation of various human myeloid leukemic cells to macrophages was determined. The results indicate that, within the group of phorbol esters tested, a correlation exists between the potency of the compounds as inducers of differentiation and their reported potency as tumor(More)
Trichothecenes are sesquiterpen mycotoxins characterized by the tetracyclic 12,13-epoxytrichothec-9-ene skeleton. We determined the effect of these mycotoxins on the growth and differentiation of the human acute promyelocytic leukemia (HL-60) cell line. Sixteen natural and semisynthetic trichothecenes were tested at concentrations of 0.2-60,000 ng/ml. The(More)
Cell cytotoxicity, inhibition of synthesis of Epstein-Barr virus (EBV) viral capsid antigen (VCA), nuclear antigen (EBNA) and transformation of human cord blood lymphocytes (CBL) by EBV, were studied using the disodium salt of phosphonoacetic acid (PAA), ethyl diethyl-phosphonoacetate (Et-PAA) and two derivatives of phosphonopropionic acid: ethyl(More)
6-Trichloromethyl-9-methylpurine (1) rearranges to 6-dichloromethyl-9-methyl-8-oxopurine (2) in aqueous mild acidic solution. The rearrangement is rationalized in terms of a reaction involving protonation, covalent hydration, prototropic equilibrium and/or a hydride transfer. An alternative mechanism involving a ‘positive’ halogen compound and hypochlorous(More)
A new classification technique for the identification of bats to species from their echolocation calls is presented. Three different datasets are compiled and split in half for training and testing classifiers. Combined, the data include 9,014 files (bat passes) with 226,432 candidate calls (pulses or extraneous noise) representing 22 different species of(More)
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