Ian Carmichael

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There have been many systems developed that attempt to recover design and structure from code. In this paper, we present our experience with using one such tool, SoFi, to extract design structure from a large industrial system written in C. We compare the extracted structure to that which was intended by the designers of the system. We observe and(More)
An extensive radiation chemistry literature would suggest that the addition of certain radical scavengers might mitigate the effects of radiation damage during protein crystallography diffraction data collection. However, attempts to demonstrate and quantify such an amelioration and its dose dependence have not yielded consistent results, either at room(More)
During macromolecular X-ray crystallography experiments, protein crystals held at 100 K have been widely reported to exhibit reproducible bond scission events at doses on the order of several MGy. With the objective to mitigate the impact of radiation damage events on valid structure determination, it is essential to correctly understand the radiation(More)
Radiation damage during macromolecular X-ray crystallographic data collection is still the main impediment for many macromolecular structure determinations. Even when an eventual model results from the crystallographic pipeline, the manifestations of radiation-induced structural and conformation changes, the so-called specific damage, within crystalline(More)
Significant progress has been made in macromolecular crystallography over recent years in both the understanding and mitigation of X-ray induced radiation damage when collecting diffraction data from crystalline proteins. In contrast, despite the large field that is productively engaged in the study of radiation chemistry of nucleic acids, particularly of(More)
[Bredenfeld 90] Bredenfeld, Ansgar, " Definition of Modeling Concepts for a Procedural Interface between VLSI-Design Tools and a Common Database " , 165 [Dimes 93a] Dimes Design and Test Centre, " DDL and DML for Meta Data Management in the Nelsis [vdHamer 94] van den Hamer, Peter; Lepoeter, Kees, " Managing Design Data-The 5 dimensions of CAD Frameworks,(More)
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