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The lack of potent, selective, brain penetrant Y2 receptor antagonists has hampered in vivo functional studies of this receptor. Here, we report the in vitro and in vivo characterization of(More)
The synthesis and preclinical characterization of novel 4-(R)-methyl-6,7-dihydro-4H-triazolo[4,5-c]pyridines that are potent and selective brain penetrant P2X7 antagonists are described. Optimization(More)