Ian C Larson

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Catechins found in green tea have received considerable attention due to their favourable biological properties which include cardioprotective, neuroprotective and anti-cancer effects. However, their therapeutic potential is limited by their low oral bioavailability, attributed to poor stability and intestinal absorption. We encapsulated (+)-catechin (C)(More)
Osteosarcoma (OS) is the most common type of malignant bone cancer, and the sixth most common type of cancer in children and young adults. Currently, gene therapy is being evaluated as a novel method for OS treatment. Here we report on an in situ gelling chitosan-based hydrogel system that sustains the release of a potential anti-cancer gene (pigment(More)
The aim of this study was to investigate the effect of coating on the aerosolization of three model micronized powders. Three model powder materials (salbutamol sulphate, salmeterol xinafoate, triamcinolone acetonide) were chosen not only for their different chemical properties but also for their different physical properties such as shape and size(More)
Purpose. The role of fine lactose in the dispersion of salmeterol xina- foate (SX) from lactose mixtures was studied by modifying the fine lactose concentration on the surface of the lactose carriers using wet decantation. Methods. Fine lactose was removed from lactose carriers by wet decantation using ethanol saturated with lactose. Particle sizing was(More)
The study investigated the role of agglomeration and the effect of fine lactose size on the dispersion of salmeterol xinafoate (SX) from SX–lactose mixtures for inhalation. Particle size distributions were characterised by Malvern Mastersizer S, Aerosizer and Spraytec, and imaging conducted by scanning electron microscopy (SEM). Inter-particulate adhesion(More)
Phytantriol (3,7,11,15-tetramethylhexadecane-1,2,3-triol, PHYT) is a cosmetic ingredient that exhibits similar lyotropic phase behavior to monoolein (GMO), forming bicontinuous cubic liquid crystalline structures (Q(II)) at low temperatures and reversed hexagonal phase (H(II)) at higher temperatures in excess water. Despite these similarities, phytantriol(More)
The in vitro dispersion of salmeterol xinafoate (SX) alone and four SX (2.5%)-coarse lactose (CL) mixtures containing 0%, 5%, 10% and 20% micronised lactose (ML) was monitored during 18-month storage at 33%, 55% and 75% relative humidity (RH) using a twin stage impinger. The surface moisture was monitored over 2 months by thermo gravimetric analysis. The(More)
The purpose was to calculate distributions of powder strength of a cohesive bed to explain the de-agglomeration of lactose. De-agglomeration profiles of Lactohale 300® (L300) and micronized lactose (ML) were constructed by particle sizing aerosolised plumes dispersed at air flow rates of 30–180 l/min. The work of cohesion distribution was determined by(More)
This study investigated the relationship between surface energy of micronized lactose, coarse lactose and salmeterol xinafoate and dispersibility from a mixture after storage at 75% RH. Surface energies, dispersibility, morphology, and the presence of amorphous domains were determined by inverse gas chromatography, twin stage impinger, scanning electron(More)
The objective of this study was to investigate the effect of particle surface coating with magnesium stearate on the aerosolization of dry powder inhaler formulations. Micronized salbutamol sulphate as a model drug was dry coated with magnesium stearate using a mechanofusion technique. The coating quality was characterized by X-ray photoelectron(More)