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1. ZENECA ZD7288 (4-(N-ethyl-N-phenylamino)-1,2-dimethyl-6-(methylamino) pyridinium chloride) is a sinoatrial node (SAN) modulating agent which produces a selective slowing of the heart rate. Its effects have been studied in single, freshly dissociated guinea-pig SAN cells, by standard patch clamp procedures. 2. Whole-cell inward currents were evoked by(More)
Virtually all real-valued computations are carried out using floating-point data types and operations. The precision of these data types must be set with the goals of reducing the overall round-off error, but also emphasizing performance improvements. Often, a mixed-precision allocation achieves this optimum; unfortunately, there are no techniques available(More)
This report presents preliminary results from ongoing research into the potential performance improvements of the unikernel programming model over traditional operating systems in virtualized environments. We compare OSv to a typical Linux server in DNS and HTTP server benchmarks and find that OSv seems to provide an appreciable performance improvement even(More)
L-2-Chloropropionic acid (L-CPA), when orally administered at single high dose to rats produces a selective lesion in the cerebellum involving destruction of a high proportion of granule cells by a mechanism which involves N-methyl-D-aspartate (NMDA) receptors. Receptor binding studies demonstrated that L-CPA a had low affinity at the glutamate and glycine(More)
The effects of opioids were studied on the dorsal root-dorsal root evoked potential (DRP) of the neonatal hemisected spinal cord of the rat in vitro. Applications of [D-Ala2,Met5]enkephalinamide (DAME), [D-Ala2,D-Leu5]enkephalin (DADL), Leu5 enkephalin, Met5 enkephalin, Dynorphin 1-9 and normorphine produced dose-dependent depressions of the dorsal root(More)
Depletion of rat brain serotonin by p-chlorophenylalanine (PCPA) pretreatment, or of monoamines by reserpine pretreatment, was associated with reduced spontaneous firing rates of bulbar reticular neurones. Administration of 5-hydroxytryptophan to PCPA-treated rats reversed the reduction of neuronal activity. It is suggested that the results indicate a tonic(More)
1. The micro-iontophoretic technique has been used to study the responses of single neurones in the bulbar reticular formation to 5-hydroxytryptamine and to noradrenaline, ACh or glutamate, and to compare these with the responses to electrical stimulation in or near the bulbar raphe nuclei. 2. In the bulbar reticular formation, most neurones were excited by(More)
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