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The motor hand function of 16 children, aged between 4 and 7 years, with developmental speech and language disorders, was compared with that of 16 control children. The children with developmental speech and language disorders were significantly slower than controls on three out of four motor tasks. They were also more likely than controls to have mixed(More)
Neurodevelopmental disorders could be caused by maternal antibodies or other serum factors. We detected serum antibodies binding to rodent Purkinje cells and other neurons in a mother of three children: the first normal, the second with autism, and the third with a severe specific language disorder. We injected the serum (0.5-1.0 ml/day) into pregnant mice(More)
The ability of normal and clumsy children to match the length of lines within and between the modalities of vision and kinesthesis was studied. The clumsy children showed perceptual impairments, as indicated by their poor performance on the visual, kinaesthetic and cross-modal judgements of length and also by their low scores on spatial subtests of the(More)
Eleven infants with neonatal onset of intractable epilepsy are described, who showed the clinical and electroencephalographic features of Ohtahara syndrome. With time, transition to West and Lennox-Gastaut syndromes occurred. No cause could be found in eight cases. All nine survivors are severely mentally and physically handicapped and continue to have(More)
One hundred and eighty-six consecutive children aged between six and 72 months admitted to the Manchester Children's Hospitals with a febrile convulsion in the first year of life, a complicated febrile convulsion, or more than one febrile convulsion within two years, were allocated randomly to one of three groups who were offered rectal diazepam in the(More)
Adult-centred studies continue to show poor information provision and understanding in people with epilepsy. This study explores whether paediatric neurologists work within a consultation framework designed to meet information needs. A questionnaire on how to give the diagnosis was sent to 32 UK Paediatric Neurologists. Consultation content was largely(More)
In a previous study, clumsy children, when compared to normal children of the same age, were found to be impaired in their ability to match the length of successively presented straight lines within and between the modalities of vision and kinaesthesis. The present study explores this finding further by comparing the clumsy children's performance with that(More)
  • A G Sutcliffe, S W D'Souza, J Cadman, B Richards, I A McKinlay, B Lieberman
  • 1995
A cohort of 91 children from cryopreserved embryos and 83 control children who were conceived normally had their development assessed using the Griffiths's scales of mental development. The controls (81 singletons and two twins) of a similar age, sex, and social class were selected from siblings, cousins, and peers of the cryopreserved embryo group (68(More)