Modern speech synthesis systems with very high intelligibility are readily available in a number of languages. However, the output from all present systems is still readily identifiable as being machine-generated-the output does not sound "natural". One aspect of naturalness is the variability introduced by the emotional state of the speaker, and related… (More)
Mesenchymal stem/stromal cells (MSCs) can regenerate tissues by direct differentiation or indirectly by stimulating angiogenesis, limiting inflammation, and recruiting tissue-specific progenitor cells. MSCs emerge and multiply in long-term cultures of total cells from the bone marrow or multiple other organs. Such a derivation in vitro is simple and… (More)
A system for producing synthetic speech which incorporates vocal emotion effects has been developed. This has been incorporated into a communication prosthesis for non-vocal people to give them more freedom of expression via a synthetic voice. A range of common emotions can be simulated by the system.
Mesenchymal stem/stromal cells (MSCs) and MSC-like multipotent stem/progenitor cells have been widely investigated for regenerative medicine and deemed promising in clinical applications. In order to further improve MSC-based stem cell therapeutics, it is important to understand the cellular kinetics and functional roles of MSCs in the dynamic regenerative… (More)
Focal chondral defects of the articular surface are a common occurrence in the field of orthopaedics. These isolated cartilage injuries, if not repaired surgically with restoration of articular congruency, may have a high rate of progression to posttraumatic osteoarthritis, resulting in significant morbidity and loss of function in the young, active… (More)