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- Iain L C Chapple, John B. Matthews
- Periodontology 2000
- 2007
- John B. Matthews, H. Jeffrey Wright, Alice Roberts, P R Cooper, Iain L C Chapple
- Clinical and experimental immunology
- 2007
Some evidence exists that peripheral neutrophils from patients with chronic periodontitis generate higher levels of reactive oxygen species (ROS) after Fcgamma-receptor stimulation than those from… (More)
- Iain L C Chapple, Gareth R. Brock, Michael Milward, Na-jia Ling, John B. Matthews
- Journal of clinical periodontology
- 2007
BACKGROUND
Oxidative stress is implicated in the pathogenesis of periodontitis. The total antioxidant capacity (TAOC) of gingival crevicular fluid volume (GCF) and plasma appears compromised in… (More)
- John B. Matthews, H. Jeffrey Wright, Alice Roberts, Nic Ling-Mountford, P R Cooper, Iain L C Chapple
- Journal of dental research
- 2007
Peripheral neutrophil hyper-responsiveness in chronic periodontitis leads to excessive reactive oxygen species (ROS) production. We aimed to determine whether neutrophil hyper-responsiveness was… (More)
- Iain L C Chapple
- Journal of clinical periodontology
- 1997
This paper aims to review the rôle of free radical-induced tissue damage and antioxidant defence mechanisms in inflammatory diseases that involve pathogenic processes similar to the periodontal… (More)
- Iain L C Chapple, Robert J. Genco
- Journal of periodontology
- 2013
BACKGROUND
Diabetes and periodontitis are complex chronic diseases with an established bidirectional relationship. There is long-established evidence that hyperglycaemia in diabetes is associated… (More)
- Paola de Pablo, Iain L C Chapple, Christopher D Buckley, Thomas Dietrich
- Nature Reviews Rheumatology
- 2009
Periodontitis is a chronic inflammatory disease that is characterized by loss of the periodontal ligament and alveolar bone, and is a major cause of tooth loss. Results from clinical and… (More)
- Iain L C Chapple, Mike R Milward, Thomas Dietrich
- The Journal of nutrition
- 2007
Chronic periodontitis is an inflammatory disease that affects the supporting tissues of the teeth. It is initiated by specific bacteria within the plaque biofilm and progresses due to an abnormal… (More)
- P R Cooper, Lisa J Palmer, Iain L C Chapple
- Periodontology 2000
- 2013
The discovery of neutrophil extracellular traps in 2004 opened a fascinating new chapter in immune-mediated microbial killing. Brinkman et al. demonstrated that neutrophils, when catastrophically… (More)
- Melissa M Grant, Andrew J Creese, +6 authors Iain L C Chapple
- Journal of proteome research
- 2010
The 21-day experimental gingivitis model, an established noninvasive model of inflammation in response to increasing bacterial accumulation in humans, is designed to enable the study of both the… (More)