Iain H Chisholm

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A common detection and classification system is needed for epidemiologic studies of age-related maculopathy (ARM). Such a grading scheme for ARM is described in this paper. ARM is defined as a degenerative disorder in persons > or = 50 years of age characterized on grading of color fundus transparencies by the presence of the following abnormalities in the(More)
In a study of 150 consecutive patients with age-related macular disease and unilateral visual loss, the drusen in the better eye were analyzed for size, number, density, and fluorescein angiographic appearance, and these characteristics were compared with the type of the lesion causing visual loss in the contralateral eye. In the fellow eye of an eye with(More)
BACKGROUND In patients with unilateral visual loss related to age-related macular disease, the risk of visual loss in the second eye is documented as being between 7% and 10% per year. The risk is uncertain in those with good vision with each eye and bilateral macular drusen. METHODS In a prospective study, 126 patients with bilateral drusen were reviewed(More)
Observation of patients with Sorsby's fundus dystrophy has shown that a prolonged choroidal filling phase on fluorescein angiography may indicate the presence of diffuse thickening of Bruch's membrane. We analyzed fluorescein angiography transit photographs in 100 eyes of 100 consecutive patients with age-related changes at the level of Bruch's membrane. Of(More)
Development of senile disciform degeneration in the second eye was studied in a group of 104 patients over a period of up to five years. 12 to 15% of these patients develop disciform degeneration in the other eye each year. Patients with large and confluent drusen, especially if combined with accumulation of dye on fluorescein angiogram, were at greatest(More)
A case is presented of cortical blindness in cranial arteritis. A clinical diagnosis at the time of presentation was based on the integrity of the pupillary light reflex and the absence of visually evoked responses. Pathological examination confirmed bilateral occipital infarction. This report stresses the need for recognizing this presentation of cranial(More)
OBJECTIVE To determine whether teletherapy with 6-mV photons can reduce visual loss in patients with subfoveal choroidal neovascularization in age-related macular degeneration. DESIGN A multicenter, single-masked, randomized controlled trial of 12 Gy of external beam radiation therapy delivered to the macula of an affected eye vs observation only. (More)