Iain D Ridgway

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Bivalve molluscs are newly discovered models of successful aging, and this invertebrate group includes Arctica islandica, with the longest metazoan life span. Despite an increasing biogerontological focus on bivalves, their life history traits in relation to maximum age are not as comprehensively understood as those in vertebrate model aging organisms. We(More)
We assess whether reactive oxygen species production and resistance to oxidative stress might be causally involved in the exceptional longevity exhibited by the ocean quahog Arctica islandica. We tested this hypothesis by comparing reactive oxygen species production, resistance to oxidative stress, antioxidant defenses, and protein damage elimination(More)
Bivalve species with exceptional longevity are newly introduced model systems in biogerontology to test evolutionarily conserved mechanisms of aging. Here, we tested predictions based on the oxidative stress hypothesis of aging using one of the tropical long-lived sessile giant clam species, the smooth giant clam (Tridacna derasa; predicted maximum life(More)
The ocean quahog, Arctica islandica is not just the longest living bivalve, it is also the longest lived, non-colonial animal known to science. With the maximum life span potential ever increasing and currently standing in excess of 400 years the clam has recently gained interest as a potential model organism for ageing research. This review details what is(More)
In this article, we explore the use of fluorescence spectroscopy to image growth patterns in the marine bivalve Arctica islandica (L.). The method presented here does not require any chemical treatment of the polished shell section and yields results comparable to acetate peels of acid-etched shell sections and Mutveitreated shell sections. Further, our(More)
Nonylphenol and octylphenol have been identified as endocrine disrupters with the ability to cause reproductive deformities in a number of organisms. A normal phase high-performance liquid chromatography (HPLC) method with fluorescence detection was developed with a mobile phase of cyclohexane/methyl-tertiary-butyl ether (MTBE) (70 + 30). The extraction of(More)
The shortening of telomeres as a causative factor in ageing is a widely discussed hypothesis in ageing research. The study of telomere length and its regenerating enzyme telomerase in the longest-lived non-colonial animal on earth, Arctica islandica, should inform whether the maintenance of telomere length plays a role in reaching the extreme maximum(More)
a r t i c l e i n f o Cross-dated chronologies derived from internal growth increments in the shells of the long-lived bivalve, the dog cockle Glycymeris glycymeris (Linnaeus, 1758), live-collected from two different sites off the east (1997) and south (2009) coasts of the Isle of Man respectively, are described. The chronologies, developed from ten(More)
Bivalve molluscs are newly discovered models of successful aging. Here, we test the hypothesis that extremely long-lived bivalves are not uniquely resistant to oxidative stressors (eg, tert-butyl hydroperoxide, as demonstrated in previous studies) but exhibit a multistress resistance phenotype. We contrasted resistance (in terms of organismal mortality) to(More)
Bivalve mollusks have several unique traits, including some species with exceptionally long lives, others with very short lives, and the ability to determine the age of any individual from growth rings in the shell. Exceptionally long-lived species are seldom studied yet have the potential to be particularly informative with respect to senescence-resistance(More)