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Although preeclampsia (PE) is a major cause of maternal and fetal mortality, its pathogenesis is not fully understood. Digitalis-like cardiotonic steroids (CTS) are believed to be involved in the pathophysiology of PE, as illustrated by clinical observations that DIGIBIND, a digoxin antibody which binds CTS, lowers blood pressure in PE. Recently we reported(More)
In the sensorimotor cortical slices of guinea pigs, the rate of neurons' spike activity increased at 27-29 and 34-36 degrees C. The change of the firing rate was accompanied by a drop in the spike amplitude at the temperature below 27 and above 34 degrees C. Usually after cooling to 24 degrees C the spike amplitude fully restored when the temperature(More)
Experiments on guinea pig sensorimotor cortex slices with cooling of the incubation medium from 34°C to 21–22°C showed that hypothermia had no effect on evoked spike responses to application of glutamate to cell bodies, while application of glutamate to dendritic loci induced spike responses in the body with a short latent period with a hypothermic increase(More)
In sensorimotor cortical slices of guinea pig in the course of cooling of incubating fluid from 34 to 21-22 delta C it was shown that hypothermia does not influence on the evoked spike reactions to iontophoretic application of glutamate to the soma, but glutamate action on the dendritic locus causes the shot latency somatic spike response during hypothermic(More)
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