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The study was designed to evaluate effect of trandolapril, an ACE inhibitor, on platelet aggregation in patients with arterial hypertension and impaired glucose tolerance. The drug was given to 38 patients for 12 weeks. The key end points were dynamics of the blood lipid spectrum, lipid peroxidation in plasma and platelets, antioxidative protection of the(More)
Healthy newborn Simmental and Black Pied calves with a normal number of platelets in bloodstream don’t have reliable dynamics of the aggregation function of blood platelets with adenosine diphosphate, collagen, thrombin, ristocetin, epinephrine, as well as combinations of ADP + epinephrine, ADP + collagen, and collagen + epinephrine inducers. The level of(More)
The aim of the study was to evaluate efficiency of correction of lipid profile disturbances and platelet dysfunction by lovastatin in patients with arterial hypertension and dyslipidemia. Lovastatin was given to 29 patients for 4 months. The main parameters measured included dynamics of blood lipid profile, lipid peroxidation in plasma and platelets,(More)
During the survey of 215 indigenous inhabitants of Kursk region, the activity of chromosomal nucleolar organizing regions (NOR) was examined in peripheral blood lymphocytes by a visual semiquantitative method based on silver salt impregnation (Howell W. M., 1975), and the general anthropometric indexes were determined. Significant differences in(More)
Hypertension is the main disease in Russian Federation--its frequency is 39.2% in men and 41.1% in women. In recent years course of a disease is accompanied by the metabolic derangements which form the metabolic syndrome. In the basis of pathogenesis of hypertension are insulinresistance and compensatory hyperinsulinemia in combination with associated(More)
Low-calorie diet and individually adjusted physical exercise used in combination in hypertensive patients with metabolic syndrome correct shifts in blood lipid spectrum, relieve peroxidation syndrome, normalize impaired platelet hemostasis, suppress enhanced adhesive and aggregation functions of platelets in vitro and their intravascular activity. The(More)
The purpose of the study was to investigate the effects of hypocaloric diet (HCD) on intravascular thrombocyte activity (ITA) dynamics in patients with arterial hypertension (AH), androidal type of obesity, and glucose tolerance disorder. The subjects were 25 middle age patients with AH with metabolic syndrome (MS). Anthropometric variables, plasmatic lipid(More)
The objective of the study was to evaluate the efficiency of lovastatin correction of dyslipidemia and impaired intravascular platelet activity (IPA) in patients with arterial hypertension (AH) concurrent with metabolic syndrome (MS). Eighteen patients were given lovastatin for a month. The time course of changes in anthropometric parameters, blood lipid(More)
The aim of the study was to elucidate normalizing effect of candesartan on disturbed thrombocytic hemostasis in patients with arterial hypertension and metabolic syndrome. The drug was given for 16 weeks to 31 patients in whom dynamics of lipid peroxidation in plasma and platelets, the antioxidative potential of candesartan, and parameters of thrombocytic(More)