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Design of slowly metabolized compounds is an important goal in many drug discovery projects. Standard hepatocyte suspension intrinsic clearance (CLint) methods can only provide reliable CLint values… Expand
A key requirement in drug discovery is to accurately define intrinsic clearance (CLint) values of less than 1 µl/min/106 hepatocytes, which requires assays that allow for longer incubation time as a… Expand
A LC-MS/MS method was developed for quantitative determination of esomeprazole, and its two main metabolites 5-hydroxyesomeprazole and omeprazole sulphone in 25 microL human, rat or dog plasma. The… Expand
20th International Symposium on Microsomes and Drug Oxidations, Stuttgart, Germany, 18-22 May, 2014 Background Oral drugs typically require effective half lives in the region of 10 – 20 h for once or… Expand
For businesses to be competitive, they need an organization that promotes creativity and innovation. Creativity is something that can be difficult to regulate from within an organization. The… Expand