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  • Ia Hultman, Charlotta Vedin, Anna Abrahamsson, Susanne Winiwarter, Malin Darnell
  • Medicine, Chemistry
  • Molecular pharmaceutics
  • 2016 (First Publication: 14 July 2016)
  • Design of slowly metabolized compounds is an important goal in many drug discovery projects. Standard hepatocyte suspension intrinsic clearance (CLint) methods can only provide reliable CLint valuesExpand
  • Britta Bonn, Petter Svanberg, Annika Janefeldt, Ia Hultman, K. H. Grime
  • Medicine, Chemistry
  • Drug Metabolism and Disposition
  • 2016 (First Publication: 1 April 2016)
  • A key requirement in drug discovery is to accurately define intrinsic clearance (CLint) values of less than 1 µl/min/106 hepatocytes, which requires assays that allow for longer incubation time as aExpand
  • Ia Hultman, Helene Stenhoff, Mathias Liljeblad
  • Chemistry, Medicine
  • Journal of chromatography. B, Analytical…
  • 2007 (First Publication: 1 April 2007)
  • A LC-MS/MS method was developed for quantitative determination of esomeprazole, and its two main metabolites 5-hydroxyesomeprazole and omeprazole sulphone in 25 microL human, rat or dog plasma. TheExpand