I. Yokoi

Publications111
h-index21
Citations1,413
Highly Influential Citations27
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Melatonin Inhibits Iron‐Induced Epileptic Discharges in Rats by Suppressing Peroxidation
Summary: Purpose: Intracortical injection of iron ion induces recurrent seizures and epileptic discharges in the electrocorticogram. This observation may be used as a model of post‐traumatic… Expand
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Hydrogen-rich saline solution attenuates renal ischemia–reperfusion injury
PurposeRenal ischemia–reperfusion (I/R), an important cause of acute kidney injury, is unavoidable during various types of operations, including renal transplantation, surgical revascularization of… Expand
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Natural antioxidants may prevent posttraumatic epilepsy: a proposal based on experimental animal studies.
Head injury or hemorrhagic cortical infarction results in extravasation of blood and breakdown of red blood cells and hemoglobin. Iron liberated from hemoglobin, and hemoglobin itself, are associated… Expand
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Cobalt(II) and nickel(II) ions as promoters of free radicals in vivo: detected directly using electron spin resonance spectrometry in circulating blood in rats.
We employed an electron spin resonance (ESR)2 spectrometer and used a direct detection technique for determining free radicals in circulating blood in rats. We found that the simultaneous intravenous… Expand
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Effects of magnetic fields on the accumulation of thiobarbituric acid reactive substances induced by iron salt and H(2)O(2) in mouse brain homogenates or phosphotidylcholine.
In this study, we examined the effects of magnetic fields (MFs) on the generation of thiobarbituric acid reactive substances (TBARS) in the mouse brain homogenates or phosphotidylcholine (PC)… Expand
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α-Tocopheryl-l-ascorbate-2-O-phosphate diester, a hydroxyl radical scavenger, prevents the occurrence of epileptic foci in a rat model of post-traumatic epilepsy
Intracortical injection of iron ions has been used to model post-traumatic epilepsy. The results obtained using these models suggest that oxidation of neural membranes by active oxygen free radicals… Expand
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Effects of glutamic acid relatives on the electrical activity of an identified molluscan giant neurone (achatina fulica férussac)
Effects of glutamic acid and its relatives were examined on the electrical activity of two kinds of neurones (the PON, periodically oscillating neurone, and the TAN, tonically autoactive neurone)… Expand
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Direct detection of circulating free radicals in the rat using electron spin resonance spectrometry.
We developed a new technique for directly observing in vivo free radical formation in the circulating blood of living rats using electron spin resonance (ESR) spectrometry without any labeling or… Expand
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Neurochemical changes related to ageing in the senescence-accelerated mouse brain and the effect of chronic administration of nimodipine
The levels of neurotransmitters and related metabolic enzyme activities in the brain of young-adult (3 months old), aged (11 months old) and nimodipine-administered (11 months old)… Expand
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The effect of homoarginine on the EEG of rats.
The effect of homoarginine on electroencephalographic activity in the rat was investigated. Electroencephalograms with epidural electrodes revealed spike discharges after topical application of… Expand
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