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Highly Sensitive Protein Translation Assay for Trichothecene Toxicity in Airborne Particulates: Comparison with Cytotoxicity Assays
ABSTRACT Screening assays for environmental mycotoxins in bulk samples currently use cytotoxicity in cell cultures, but their application to air particulate samples often lacks sensitivity andExpand
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Fungal Proteases and Their Pathophysiological Effects
  • I. Yike
  • Biology, Medicine
  • Mycopathologia
  • 23 January 2011
Proteolytic enzymes play an important role in fungal physiology and development. External digestion of protein substrates by secreted proteases is required for survival and growth of both saprophyticExpand
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Infant animal model of pulmonary mycotoxicosis induced by Stachybotrys chartarum
In recent years cases of often fatal pulmonary hemorrhage in infants have been associated with water damaged homes and the toxigenic fungusStachybotrys chartarum. The fungal spores contain mycotoxinsExpand
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Stachybotrys chartarum, trichothecene mycotoxins, and damp building-related illness: new insights into a public health enigma.
Damp building-related illnesses (DBRI) include a myriad of respiratory, immunologic, and neurologic symptoms that are sometimes etiologically linked to aberrant indoor growth of the toxic black mold,Expand
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Hemolysis, Toxicity, and Randomly Amplified Polymorphic DNA Analysis of Stachybotrys chartarum Strains
ABSTRACT Stachybotrys chartarum is an indoor air, toxigenic fungus that has been associated with a number of human and veterinary health problems. Most notable among these has been a cluster ofExpand
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Initial Characterization of the Hemolysin Stachylysin from Stachybotrys chartarum
ABSTRACT Stachybotrys chartarum is a toxigenic fungus that has been associated with human health concerns, including pulmonary hemorrhage and hemosiderosis. This fungus produces a hemolysin,Expand
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Pulmonary effects of Stachybotrys chartarum in animal studies.
Publisher Summary Stachybotrys chartarum is one of the several environmental fungi that can produce very potent toxic compounds. Animal models provide physicians and environmental scientists withExpand
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Acute inflammatory responses to Stachybotrys chartarum in the lungs of infant rats: time course and possible mechanisms.
Stachybotrys chartarum has been linked to building-related respiratory problems including pulmonary hemorrhage in infants. The macrocyclic trichothecenes produced by S. chartarum have been theExpand
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The role of fungal proteinases in pathophysiology of Stachybotrys chartarum
The adverse health effects of Stachybotrys chartarum have often been linked to exposure to the trichothecene mycotoxins. Recent studies have shown that in addition to mycotoxins this fungus isExpand
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Immunocytochemical localization of stachylysin in Stachybotrys chartarum spores and spore-impacted mouse and rat lung tissue.
Stachylysin is a proteinaceous hemolytic agent that is produced by Stachybotrys chartarum. Stachylysin was found, using immunohistochemical and immunocytochemical methods, to be localized in S.Expand
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