• Publications
  • Influence
Molecular characterization of two monkey dihydrodiol dehydrogenases.
Japanese monkey liver contains multiple forms of dihydrodiol dehydrogenase with 3(20)alpha-hydroxysteroid dehydrogenase activity. Here we have purified the major and minor forms (DD1 and DD4) of theExpand
  • 20
  • 2
  • PDF
Catalytic activity of cytochrome P450 isozymes purified from rat liver in converting 11-oxo-Δ8-tetrahydrocannabinol to Δ8-tetrahydrocannabinol-11-oic acid
Cytochrome P450 isozymes purified from rat hepatic microsomes were able to catalyse the oxidation of 11-oxo-delta 8-tetrahydrocannabinol (11-oxo-delta 8-THC) to delta 8-THC-11-oic acid in theExpand
  • 15
  • 1
Possible Existence of a Novel Receptor for Uridine Analogues in the Central Nervous System Using Two Isomers, N3-(S)-(+)- and N3-(R)-(−)-α-Hydroxy-β-phenethyluridines
Uridine analogue binding sites, the so-called uridine receptor, were observed in the experiments on specific [3H]N3-phenacyluridine binding to bovine synaptic membranes using two isomers, N3-(S)-(+)-Expand
  • 10
  • 1
Cannabielsoin as a new metabolite of cannabidiol in mammals
Cannabielsoin (CBE) was identified as a novel metabolite of cannabidiol (CBD) in the guinea pig in vivo and in vitro. Its formation by liver microsomes of guinea pigs needed NADPH and molecularExpand
  • 18
  • 1
CYP3A4 Is a Major Isoform Responsible for Oxidation of 7-Hydroxy-Δ8-tetrahydrocannabinol to 7-Oxo-Δ8-tetrahydrocannabinol in Human Liver Microsomes
The human liver enzyme microsomal alcohol oxygenase was able to oxidize both 7α- and 7β-hydroxy-Δ8-tetrahydrocannabinol (7α- and 7β-hydroxy-Δ8-THC) to 7-oxo-Δ8-THC. The oxidative activity wasExpand
  • 20
  • 1
Hepatic Metabolism of Methyl Anthranilate and Methyl N-Methylanthranilate as Food Flavoring Agents in Relation to Allergenicity in the Guinea Pig
To assess the safety of the food flavoring agents, methyl anthranilate (MA) and methyl N-methylanthranilate (MNMA), their relationships with metabolism and allergenicity were examined in guinea pigs.Expand
  • 8
  • 1
  • PDF
Mutational and Comparative Analysis of Streptolysin O, an Oxygen-labile Streptococcal Hemolysin
The structural gene of streptolysin O was cloned from Streptococcus pyogenes strain Sa and S. equisimilis H46A, and the nucleotide sequences were compared with those of strain Richards. To obtain theExpand
  • 12
  • 1
Analysis and pharmacotoxicity of feruloyltyramine as a new constituent and p-coumaroyltyramine in Cannabis sativa L.
Feruloyltyramine (FT), a new amide compound, together with p-coumaroyltyramine (p-CT) was isolated and identified in ethanol extract of cannabis seeds. FT and p-CT were also detected in the roots,Expand
  • 18
  • 1
Hypotensive effect of fish protein hydrolysate
脱脂イワシ魚粉のアルカリプロテアーゼ加水分解物(FPH)を用いて, ACE阻害活性および動物試験による高血圧発症に及ぼす影響について検討し,以下の結果を得た. (1) FPHのACE阻害活性は, IC50値が0.18mgタンパク質/mlであり,他の5種のプロテアーゼによる脱脂イワシ魚粉の加水分解物と比較して最も活性が高かった. (2)Expand
  • 40
  • 1