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The Hunter Serotonin Toxicity Criteria: simple and accurate diagnostic decision rules for serotonin toxicity.
TLDR
Decision rules (the Hunter Serotonin Toxicity Criteria) were developed that were simpler, more sensitive to serotonin toxicity and less likely to yield false positives. Expand
Relative Toxicity of Selective Serotonin Reuptake Inhibitors (SSRIs) in Overdose
TLDR
This study shows SSRIs are relatively safe in overdose despite serotonin syndrome being common, and believes that cardiac monitoring should be considered in citalopram overdose, particularly with large ingestions and patients with associated cardiac disease. Expand
Relative toxicity of venlafaxine and selective serotonin reuptake inhibitors in overdose compared to tricyclic antidepressants.
TLDR
Venlafaxine and dothiepin are pro-convulsant in overdose, but less likely to cause coma than TCAs and SSRIs, and Antidepressants other thanTCAs or venlafxine should be considered in patients at risk of seizure or suicide. Expand
Serotonin toxicity: a practical approach to diagnosis and treatment
TLDR
There are several drug mechanisms that cause excess serotonin, but severe serotonin toxicity only occurs with combinations of drugs acting at different sites, most commonly including a monoamine oxidase inhibitor and a serotonin reuptake inhibitor. Expand
Safety and efficacy of intravenous N‐acetylcysteine for acetaminophen overdose: analysis of the Hunter Area Toxicology Service (HATS) database
TLDR
For patients with APAP overdose seen in the HATS database of New South Wales, Australia, in-hospital death was infrequent and hepatotoxicity was significantly less likely when IV‐NAC was administered within 8 hours after APAP ingestion compared with longer intervals. Expand
Aspiration pneumonitis in an overdose population: Frequency, predictors, and outcomes
TLDR
A number of risk factors in overdose patients that are associated with aspiration pneumonitis that may allow the early identification of these patients for appropriate observation and management are shown. Expand
Quetiapine poisoning: a case series.
TLDR
Quetiapine overdose causes central nervous system depression and sinus tachycardia and a reported dose less than 3 g and a Glasgow Coma Scale score not less than 15 predicted patients not requiring ICU admission or length of stay more than 24 hours. Expand
A model for the management of self‐poisoning
To describe the development and activity of a multidisciplinary service to manage self‐poisoning.
Oral or intravenous N-acetylcysteine: which is the treatment of choice for acetaminophen (paracetamol) poisoning?
TLDR
A shorter hospital stay, patient and doctor convenience, and the concerns over the reduction in bioavailability of oral N- acetylcysteine by charcoal and vomiting make intravenous N-acetylcy Steine preferable for most patients with acetaminophen poisoning. Expand
The Australasian Clinical Toxicology Investigators Collaboration randomized trial of different loading infusion rates of N-acetylcysteine.
TLDR
This study confirmed that early treatment with N -acetylcysteine (within 8 hours of ingestion) is more effective than later treatment and demonstrated a reduction of drug-related adverse outcomes with the 60-minute infusion. Expand
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