• Publications
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The "two-headed" latent inhibition model of schizophrenia: modeling positive and negative symptoms and their treatment
  • I. Weiner
  • Psychology, Biology
    Psychopharmacology
  • 25 February 2003
TLDR
It is shown that there are two distinct LI models, disrupted and abnormally persistent LI, and it is suggested that this "two-headed LI model" mimics two extremes of deficient cognitive switching seen in schizophrenia, excessive and retarded switching between associations, mediated by dysfunction of different brain circuitries.
Immune Activation During Pregnancy in Rats Leads to a PostPubertal Emergence of Disrupted Latent Inhibition, Dopaminergic Hyperfunction, and Altered Limbic Morphology in the Offspring: A Novel
TLDR
Prenatal immune activation induced by peripheral administration of the synthetic cytokine releaser polyriboinosinic–polyribocytidilic acid to pregnant dams may provide a neurodevelopmental model of schizophrenia that reproduces a putative inducing factor; mimics the temporal course as well as some central abnormalities of the disorder; and predicts responsiveness to antipsychotic drugs.
Modulators of the glycine site on NMDA receptors, d-serine and ALX 5407, display similar beneficial effects to clozapine in mouse models of schizophrenia
TLDR
The finding that agonists of NMDARs and clozapine can restore disrupted LI and disrupt persistent LI may point to a unique ability of the NMDA system to regulate negative and positive symptoms of schizophrenia.
Neural substrates of latent inhibition: the switching model.
  • I. Weiner
  • Psychology, Biology
    Psychological bulletin
  • 1 November 1990
TLDR
It is proposed that the preexposed stimulus loses its capacity to affect behavior in conditioning, even though it predicts reinforcement, because the hippocampus inhibits the switching mechanism of the nucleus accumbens via the subiculum-accumbens pathway.
Disruption of latent inhibition by acute administration of low doses of amphetamine
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