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The "two-headed" latent inhibition model of schizophrenia: modeling positive and negative symptoms and their treatment
  • I. Weiner
  • Psychology, Medicine
  • Psychopharmacology
  • 25 February 2003
RationaleLatent inhibition (LI), namely, poorer performance on a learning task involving a previously pre-exposed non-reinforced stimulus, is disrupted in the rat by the dopamine (DA) releaserExpand
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Immune Activation During Pregnancy in Rats Leads to a PostPubertal Emergence of Disrupted Latent Inhibition, Dopaminergic Hyperfunction, and Altered Limbic Morphology in the Offspring: A Novel
Prenatal exposure to infection is associated with increased liability to schizophrenia, and it is believed that such an association is mediated by the maternal immune response, in particular, theExpand
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The connections of the dopaminergic system with the striatum in rats and primates: an analysis with respect to the functional and compartmental organization of the striatum
This Commentary compares the connections of the dopaminergic system with the striatum in rats and primates with respect to two levels of striatal organization: a tripartite functional (motor,Expand
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Maternal immune activation leads to behavioral and pharmacological changes in the adult offspring.
Maternal exposure to viral infection has been associated with an increased risk of schizophrenia in the offspring, and it has been suggested that the maternal immune response may interfere withExpand
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The organization of the basal ganglia-thalamocortical circuits: Open interconnected rather than closed segregated
Anatomical findings in primates and rodents have led to a description of several parallel segregated basal ganglia-thalamocortical circuits leading from a distinct frontocortical area, via separateExpand
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Modulators of the glycine site on NMDA receptors, d-serine and ALX 5407, display similar beneficial effects to clozapine in mouse models of schizophrenia
RationaleSchizophrenia is characterized by disturbances in sensorimotor gating and attentional processes, which can be measured by prepulse inhibition (PPI) and latent inhibition (LI), respectively.Expand
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Using the pharmacology of latent inhibition to model domains of pathology in schizophrenia and their treatment
Latent inhibition (LI) is a cross species selective attention phenomenon reflecting a modulating effect of past experience with inconsequential stimuli on current task performance involving theseExpand
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The connections of the primate subthalamic nucleus: indirect pathways and the open-interconnected scheme of basal ganglia-thalamocortical circuitry
The current view of basal ganglia organization holds that functionally corresponding subregions of the frontal cortex, basal ganglia and thalamus form several parallel segregated basalExpand
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Neural substrates of latent inhibition: the switching model.
  • I. Weiner
  • Psychology, Medicine
  • Psychological bulletin
  • 1990
Latent inhibition (LI) refers to decrement in conditioning to a stimulus as a result of its prior nonreinforced preexposure. It is a robust phenomenon that has been demonstrated in a variety ofExpand
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Disruption of latent inhibition by acute administration of low doses of amphetamine
In the latent inhibition (LI) paradigm, nonreinforced preexposure to a stimulus retards subsequent conditioning to that stimulus. Three experiments investigated the effects of acute amphetamineExpand
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