• Publications
  • Influence
Epigenetic programming by maternal behavior
TLDR
It is shown that an epigenomic state of a gene can be established through behavioral programming, and it is potentially reversible, suggesting a causal relation among epigenomicState, GR expression and the maternal effect on stress responses in the offspring.
Reversal of Maternal Programming of Stress Responses in Adult Offspring through Methyl Supplementation: Altering Epigenetic Marking Later in Life
TLDR
It is reported that methionine infusion reverses the effect of maternal behavior on DNA methylation, nerve growth factor-inducible protein-A binding to the exon 17 promoter, GR expression, and hypothalamic-pituitary-adrenal and behavioral responses to stress, suggesting a causal relationship among epigenomic state, GRexpression, and stress responses in the adult offspring.
The Transcription Factor Nerve Growth Factor-Inducible Protein A Mediates Epigenetic Programming: Altering Epigenetic Marks by Immediate-Early Genes
TLDR
Site-directed mutagenesis assays demonstrate that NGFI-A binding to the exon 17 GR promoter is required for epigenetic reprogramming of GR expression, and Knockdown experiments of NGfi-A in hippocampal primary cell culture show that NG FI-A is necessary for serotonin-induced DNA demethylation and increased exon17 GR promoter expression.
Maternal Care Associated with Methylation of the Estrogen Receptor-α1b Promoter and Estrogen Receptor-α Expression in the Medial Preoptic Area of Female Offspring
TLDR
In the present studies, cross-fostering confirmed an association between maternal care and ERα expression in the MPOA; the biological offspring of low LG mothers fostered at birth to high LG dams show increased ERα Expression in theMPOA.
Natural variations in maternal care are associated with estrogen receptor alpha expression and estrogen sensitivity in the medial preoptic area.
TLDR
It is suggested that natural variations in maternal care are associated with differences in ER alpha expression in the MPOA and that such differences are transmitted from the mother to her female offspring.
Maternal care effects on the hippocampal transcriptome and anxiety-mediated behaviors in the offspring that are reversible in adulthood.
TLDR
It is reported that TSA and methionine treatment reversed the effect of maternal care on open-field behavior, and >900 genes stably regulated by maternal care were identified.
Maternal care associated with methylation of the estrogen receptor-alpha1b promoter and estrogen receptor-alpha expression in the medial preoptic area of female offspring.
TLDR
It is suggested that maternal care is associated with cytosine methylation of the ERalpha1b promoter, providing a potential mechanism for the programming of individual differences in ERalpha expression and maternal behavior in the female offspring.
Early Environmental Regulation of Hippocampal Glucocorticoid Receptor Gene Expression: Characterization of Intracellular Mediators and Potential Genomic Target Sites
TLDR
Evidence in favor of glucocorticoid receptor gene expression in the hippocampus and hypothalamic‐pituitary‐adrenal responses to acute or chronic stress as well as recent studies describing regulatory targets within the chromatin structure of the promoter region of the rat hippocampal glucocortex receptor gene are summarized.
...
1
2
3
4
5
...