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Cholinolytics in the treatment of anticholinesterase poisoning. V. The effectiveness of Parpanit with oximes in the treatment of organophosphorus poisoning.
The effectiveness of Parpanit in the treatment of organophosphorus poisoning was examined and compared with that of atropine sulfate. The potency of Parpanit was assessed in the mouse, rat, hamster,Expand
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The induction of methaemoglobinemia as an adjunct to therapy for tabun poisoning.
The protective and therapeutic effectiveness of p-aminopropiophenone (PAPP) against tabun poisoning in the rat has been examined. The relationship between dosage of PAPP and percentage of methaemog...
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Cholinolytics in the treatment of anticholinesterase poisoning. II. Treatment of sarin poisoning with an oxime and various combinations of cholinolytic compounds.
Thirty-four cholinolytic compounds were screened for protective activity in mice and rats exposed to sarin. All compounds were examined at a dosage of 50 μmoles/kg in the presence of 30 mg/kg of N-...
  • 3
Oral prophylaxis for anticholinesterase poisoning.
A method of protection against poisoning by cholinesterase inhibitors involving the use of N-methyl pyridinium-2-aldoxime methanesulphonate (P-2-S) orally, prior to exposure to the anticholinestera...
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PREPARATION OF ANTIDOTES FOR ANTICHOLINESTERASE POISONING III. ESTERS OF 1-ARYLCYCLOALKANECARBOXYLIC ACIDS
In preceding papers of this series (1, 2) the preparation of several analogues of 5'diethylaminoethyl 1-phenylcyclopentanecarboxylate hydrochloride (Parpanit) and certain of their quaternary saltsExpand
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Cholinolytics in the treatment of anticholinesterase poisoning. I. The effectiveness of certain cholinolytics in combination with an oxime for treatment of sarin poisoning.
The protection to sarin poisoning afforded mice by treatment with N-methylpyridinium-2-aldoxime methanesulphonate (P-2-S) in combination with each of 34 cholinolytic compounds used as substitutes forExpand
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Oxime mixtures and atropine in the protection of mice and rats from sarin poisoning.
The protection provided by oral administration of mixtures of oximes prophylactically in conjunction with intramuscular atropine given therapeutically against sarin poisoning in the rat and mouse isExpand
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CHOLINOLYTICS IN THE TREATMENT OF ANTICHOLINESTERASE POISONING. III. THE EFFECTS OF QUATERNIZATION AND ALTERATION OF ANIONIC FUNCTION OF THE POTENCY OF CHOLINOLYTICS IN THE TREATMENT OF SARIN
Twenty-one quaternary ammonium salts of cholinolytic drugs have been assessed for potency against Sarin poisoning in mice and rats in a treatment using N-methylpyridinium-2-aldoxime methanesulphona...
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Cholinolytics in the treatment of anticholinesterase poisoning. IV. The effectiveness of five binary combinations of cholinolytics with oximes in the treatment of organophosphorus poisoning.
The selection, for use in combatting organophosphorus poisoning, of five binary cholinolytic drug combinations from previously screened compounds is described. Their effectiveness was determined in...
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