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A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases
The NOD-like receptor (NLR) family, pyrin domain–containing protein 3 (NLRP3) inflammasome is a component of the inflammatory process, and its aberrant activation is pathogenic in inherited disordersExpand
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Methods Used to Evaluate Pain Behaviors in Rodents
Rodents are commonly used to study the pathophysiological mechanisms of pain as studies in humans may be difficult to perform and ethically limited. As pain cannot be directly measured in rodents,Expand
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Conus Venom Peptide Pharmacology
Conopeptides are a diverse group of recently evolved venom peptides used for prey capture and/or defense. Each species of cone snails produces in excess of 1000 conopeptides, with thoseExpand
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Evolution of separate predation- and defence-evoked venoms in carnivorous cone snails
Venomous animals are thought to inject the same combination of toxins for both predation and defence, presumably exploiting conserved target pharmacology across prey and predators. Remarkably, coneExpand
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Amplified Cold Transduction in Native Nociceptors by M-Channel Inhibition
Topically applied camphor elicits a sensation of cool, but nothing is known about how it affects cold temperature sensing. We found that camphor sensitizes a subpopulation of menthol-sensitive nativeExpand
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Pathophysiology of Chemotherapy-Induced Peripheral Neuropathy
Chemotherapy-induced neuropathy is a common, dose-dependent adverse effect of several antineoplastics. It can lead to detrimental dose reductions and discontinuation of treatment, and severelyExpand
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Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a
Human genetic studies have implicated the voltage-gated sodium channel NaV1.7 as a therapeutic target for the treatment of pain. A novel peptide, μ-theraphotoxin-Pn3a, isolated from venom of theExpand
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Ciguatoxins activate specific cold pain pathways to elicit burning pain from cooling
Ciguatoxins are sodium channel activator toxins that cause ciguatera, the most common form of ichthyosarcotoxism, which presents with peripheral sensory disturbances, including the pathognomonicExpand
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Characterization of endogenous calcium responses in neuronal cell lines.
An increasing number of putative therapeutic targets have been identified in recent years for the treatment of neuronal pathophysiologies including pain, epilepsy, stroke and schizophrenia. Many ofExpand
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An animal model of oxaliplatin-induced cold allodynia reveals a crucial role for Nav1.6 in peripheral pain pathways
Summary Cold allodynia elicited by local intraplantar injection of the chemotherapeutic agent oxaliplatin is mediated through Nav1.6‐expressing peripheral sensory fibres. Activation of Nav1.6 aloneExpand
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