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Health economic burden that wounds impose on the National Health Service in the UK
Wounds impose a substantial health economic burden on the UK's NHS, comparable to that of managing obesity (£5.0 billion), and clinical and economic benefits could accrue from improved systems of care and an increased awareness of the impact that wounds impose on patients and the NHS.
Non-ionic surfactant based vesicles (niosomes) in drug delivery
Health economic burden that different wound types impose on the UK's National Health Service
Clinical and economic benefits to both patients and the NHS could accrue from strategies that focus on (a) wound prevention, (b) accurate diagnosis and (c) improving wound‐healing rates.
Dendrimers in gene delivery.
Non-ionic surfactant vesicles (niosomes): Physical and pharmaceutical chemistry
Gene delivery with synthetic (non viral) carriers.
The Lower-Generation Polypropylenimine Dendrimers Are Effective Gene-Transfer Agents
- B. Zinselmeyer, S. Mackay, A. Schatzlein, I. Uchegbu
- Chemistry, BiologyPharmaceutical Research
- 1 July 2002
The generation 2 polypropylenimine dendrimer combines a sufficient level of DNA binding with a low level of cell cytoxicity to give it optimum in vitro gene transfer activity.
Enhanced oral absorption of hydrophobic and hydrophilic drugs using quaternary ammonium palmitoyl glycol chitosan nanoparticles.
- Adeline Siew, H. Le, Marion Thiovolet, P. Gellert, A. Schatzlein, I. Uchegbu
- Chemistry, BiologyMolecular pharmaceutics
A triple action nanomedicine from a chitosan amphiphile: quaternary ammonium palmitoyl glycol chitOSan (GCPQ) significantly enhances the oral absorption of hydrophobic drugs and, to a lesser extent, the absorption ofhydrophilic drugs.
The release of model macromolecules may be controlled by the hydrophobicity of palmitoyl glycol chitosan hydrogels.
Strategies to deliver peptide drugs to the brain.
Noninvasive methods of delivering peptides to the brain include the use of chitosan amphiphile nanoparticles for oral delivery and nose to brain strategies and protecting peptides from plasma degradation is integral to the success of most of these peptide delivery strategies.