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Synthesis of cytotoxic derivatives of 2-oxo-1-azetidinylacetamide
New derivatives of 2-oxo-1-azetidinylacetamide have been synthesized by the four-component condensation of β-amino acids with aldehydes and isonitriles. Study of their cytotoxic activity in vitroExpand
Electrochemical oxidation of 4-monoalkyl-substituted 1,4-dihydropyridines
The electrochemical oxidation of 4-monoalkyl-substituted 1,4-dihydropyridines has been studied in an aprotic medium and in the presence of pyridine. In an aprotic medium the products of oxidation areExpand
Heteronuclear correlation experiments for the determination of one-bond coupling constants
Spin-state selective experiments, HSQC-α/β and CT-HMQC-α/β, are proposed for the simple and rapid measurement of scalar one-bond coupling constants in two-dimensional,1 H-detected 15N-1H or13 C-1HExpand
Synthesis and antitumor activity of selected 7-alkylidene substituted cephems.
Selected 7-alkylidene substituted cephems were synthesized and subjected to antitumor assay. The effect of substituents was examined to establish structure-activity relationships. It was found thatExpand
Electrochemical Oxidation of Compounds Containing 1,4-Dihydropyridine and Pyridinium Rings — Analogs of Gene Transfection Agents
A study was carried out on the electrochemical oxidation of 1,4-dihydropyridines, found as substituents in pyridinium salts, which are strong electron acceptors. The potentials for their oxidation inExpand
Synthesis of penicillin derivatives and study of their cytotoxic properties
By the interaction of heterocyclic thiols with sulfoxides of 6,6-dihydro- and 6α-chloropenicillanates, derivatives of 4-heteryldithio-2-azetidinones have been synthesized, as well as products ofExpand
Intermediates of Prostanoid Synthesis. Stereospecific conversion of (+)‐5β‐hydroxycyclopenten‐2‐yl‐1β‐acetic acid γ‐lactone into
Starting from (+)-5β-hydroxycyclopenten-2-yl-1β-acetic acid γ-lactone (1), (+)-1β-methoxycarbonylmethyl-2β, 3β-(p-nitrobenzylidene)-dioxycyclopentan-5-one (7) was prepared within 4 steps. SubsequentExpand
Synthesis and chemical properties of 8-aryl-7-acyl-1-6-dimethyl-6-hydroxy-4-cyano-5,6,7,8-tetrahydro-3(2H)-isoquinolinones and isoquinolinethiones
Abstract8-Aryl-7-acetyl-1, 6-dimethyl-6-hydroxy-4-cyano-5, 6, 7, 8-tetrahydro-3(2H)-isoquinolinones and -isoquinolinethiones and their sodium salts were obtained by the reaction of cyanoacetamide andExpand
Electrochemical synthesis of 1,2,3,4,4,5,6-substituted 1,4-dihydropyridines
It has been shown that chemical oxidation of the methyl ester of 3,4,5-trimethoxycarbonyl-1,2,6-trimethyl-1,4-dihydropyridine to the pyridinium salt, requiring forcing experimental conditions, may beExpand
New biological properties of tert-butyl cephalosporanate sulfones
Abstract tert-Butyl cephalosporanate 1,1-dioxides variously substituted in positions 7 and 3 were obtained from7-amino-deacetoxycephalosporanic acid (7-ADCA) and 7-aminocephalosporanic acid (7-ACA).Expand