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Oxidative stress in patients with obstructive sleep apnea syndrome
Evidence is provided that obstructive sleep apnea per se might be associated with increased oxidative burden possibly via GSH/GSSG pathway.
The acute effect of smoking in healthy and asthmatic smokers
Eur J Clin Invest 2010; 40 (2): 103–109
Atopic diseases and inflammation of the brain in the pathogenesis of autism spectrum disorders
Serum IL-6 and TNF may define an ASD subgroup that benefits most from treatment with the natural flavonoid luteolin, and formulations targeting focal inflammation of the brain could have great promise in the treatment of ASD.
Extracellular vesicles are increased in the serum of children with autism spectrum disorder, contain mitochondrial DNA, and stimulate human microglia to secrete IL-1β
These findings provide novel information that may help explain what triggers inflammation in the brain of children with ASD and could lead to novel effective treatments.
Endothelial Progenitor Cells in the Pathogenesis of Idiopathic Pulmonary Fibrosis: An Evolving Concept
The current data suggest that inadequate levels of early EPCs may potentially contribute to suppressed repair and recovery of the damaged pulmonary endothelium and thereby may drive the sequence of events in profibrogenic direction.
Neuropeptides CRH, SP, HK-1, and Inflammatory Cytokines IL-6 and TNF Are Increased in Serum of Patients with Fibromyalgia Syndrome, Implicating Mast Cells
It is reported that the neuropeptides corticotropin-releasing hormone (CRH), substance P (SP), and SP-structurally-related hemokinin-1 (HK-1) were significantly elevated in patients with FMS and this indicates that neuropePTides could stimulate MCs to secrete inflammatory cytokines that contribute importantly to the symptoms of FMS.
Matrix metalloproteinases in respiratory diseases: from pathogenesis to potential clinical implications.
The basic principles of MMP biology are presented and the clinical and experimental evidence related to MMP activity in various lung disorders, including lung cancer, pleural effusions, chronic obstructive pulmonary disease, asthma, acute respiratory distress syndrome and interstitial lung diseases are focused on.