Multidisciplinary research priorities for the COVID-19 pandemic: a call for action for mental health science
- E. Holmes, R. O’Connor, E. Bullmore
- MedicineLancet psychiatry
- 15 April 2020
Dissociating pain from its anticipation in the human brain.
- A. Ploghaus, I. Tracey, J. Rawlins
- Psychology, MedicineScience
- 18 June 1999
Functional magnetic resonance imaging in healthy humans was applied to dissociate neural activation patterns associated with acute pain and its anticipation to find sites within the medial frontal lobe, insular cortex, and cerebellum distinct from, but close to, locations mediating pain experience itself.
Imaging how attention modulates pain in humans using functional MRI.
- Susanna Bantick, R. Wise, A. Ploghaus, S. Clare, Stephen M. Smith, I. Tracey
- Psychology, BiologyBrain : a journal of neurology
- 1 February 2002
Functional MRI was used to elucidate the underlying neural systems and mechanisms involved in reduced pain perception and showed brain areas associated with the affective division of the anterior cingulate cortex and orbitofrontal regions showed increased activation when subjects were distracted during painful stimulation.
Imaging Attentional Modulation of Pain in the Periaqueductal Gray in Humans
- I. Tracey, A. Ploghaus, P. Matthews
- Psychology, BiologyJournal of Neuroscience
- 1 April 2002
High-resolution functional magnetic resonance imaging was used to define brain activation to painful heat stimulation applied to the hand of nine normal subjects within the periaqueductal gray region, providing direct evidence supporting the notion that the perianal gray is a site for higher cortical control of pain modulation in humans.
Exacerbation of Pain by Anxiety Is Associated with Activity in a Hippocampal Network
- A. Ploghaus, C. Narain, I. Tracey
- Psychology, BiologyJournal of Neuroscience
- 15 December 2001
This finding suggests that accurate preparatory information during medical and dental procedures alleviates pain by disengaging the hippocampus, and supports the proposal that during anxiety, the hippocampal formation amplifies aversive events to prime behavioral responses that are adaptive to the worst possible outcome.
A common neurobiology for pain and pleasure
Understanding the mutually inhibitory effects that pain and reward processing have on each other, and the neural mechanisms that underpin such modulation, is important for alleviating unnecessary suffering and improving well-being.
The Effect of Treatment Expectation on Drug Efficacy: Imaging the Analgesic Benefit of the Opioid Remifentanil
- U. Bingel, V. Wanigasekera, I. Tracey
- Psychology, MedicineScience Translational Medicine
- 16 February 2011
Using sophisticated brain imaging techniques, the authors show that one’s expectation of the success of a pain treatment can markedly influence its effectiveness, and how divergent expectancies alter the analgesic efficacy of a potent opioid in healthy volunteers by using brain imaging.
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