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Nucleic Acids: Structures, Properties, and Functions
Providing a comprehensive account of the structures and physical chemistry properties of nucleic acids, with special emphasis on biological function, this text is for those with only a basic…
Improved estimation of secondary structure in ribonucleic acids.
TLDR
This method can be used for predicting and assessing possible secondary structures for recently determined RNA sequences and new experimental and theoretical results allow us to improve the method, without making it more complicated.
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RNA translocation and unwinding mechanism of HCV NS3 helicase and its coordination by ATP
TLDR
This work follows in real time, at a resolution of two base pairs and 20 ms, the RNA translocation and unwinding cycles of a hepatitis C virus helicase (NS3) monomer, a representative superfamily-2 helicase essential for viral replication, and therefore a potentially important drug target.
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How RNA folds.
TLDR
A folding algorithm to predict the structure of an RNA from its sequence is suggested, but to solve the RNA folding problem one needs thermodynamic data on tertiary structure interactions, and identification and characterization of metal-ion binding sites.
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Estimation of Secondary Structure in Ribonucleic Acids
A simple method for estimating the secondary structure of an RNA molecule has been proposed on the basis of the knowledge of its sequence.
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Absorbance melting curves of RNA.
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Verification of the Crooks fluctuation theorem and recovery of RNA folding free energies
TLDR
It is shown that the Crooks fluctuation theorem can be used to determine folding free energies for folding and unfolding processes occurring in weak as well as strong nonequilibrium regimes, thereby providing a test of its validity under such conditions.
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Following translation by single ribosomes one codon at a time
TLDR
Pause lengths, and thus the overall rate of translation, depend on the secondary structure of the mRNA; the applied force destabilizes secondary structure and decreases pause durations, but does not affect translocation times.
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Stability of ribonucleic acid double-stranded helices.
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A frameshifting stimulatory stem loop destabilizes the hybrid state and impedes ribosomal translocation
TLDR
It is proposed that the downstream structure traps ribosomal complexes in the fluctuating conformational states of the translocation process and thus allows more opportunities for frameshifting, which would allow the PRE complex to explore alternative translocation pathways such as −1PRF.
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