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Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species
TLDR
The results provide evidence for a unique metabolic role for p53, linking glutamine metabolism, energy, and ROS homeostasis, which may contribute to p53 tumor suppressor function. Expand
toxB Gene on pO157 of Enterohemorrhagic EscherichiacoliO157:H7 Is Required for Full Epithelial Cell Adherence Phenotype
TLDR
The results suggest that ToxB contributes to the adherence of EHEC to epithelial cells through promotion of the production and/or secretion of type III secreted proteins. Expand
SdiA, an Escherichia coli homologue of quorum‐sensing regulators, controls the expression of virulence factors in enterohaemorrhagic Escherichia coli O157:H7
TLDR
It is found that SdiA, an Escherichia coli LuxR homologue, is a negative regulator of the expression of virulence factors EspD and intimin in enterohaemorrhagic E. coli (EHEC) O157:H7. Expand
Characterization and distribution of binding sites for the hypothalamic peptide, pituitary adenylate cyclase-activating polypeptide.
TLDR
Results suggest that 1) a saturable, high affinity binding site for PACAP is present on anterior pituitary membranes; 2) PACAP27 and PACAP38, but not VIP, share this binding site in the anterior pituitsary and possibly the hypothalamus; and 3)PACAP27, PACAP 38, and VIP share a similar or identical binding site on lung membranes and possibly other peripheral tissues. Expand
Bicarbonate Ion Stimulates the Expression of Locus of Enterocyte Effacement-Encoded Genes in Enterohemorrhagic Escherichia coli O157:H7
TLDR
It is observed that EH EC grown in Dulbecco's modified Eagle's medium (DMEM) adhered more efficiently to Caco-2 cells than EHEC grown in Luria-Bertani (LB) broth, which may imply that NaHCO3 is an important signaling factor for promoting colonization of EhEC in the lower intestinal tract in humans. Expand
Increased Adherence to Caco-2 Cells Caused by Disruption of the yhiE and yhiF Genes in Enterohemorrhagic Escherichia coli O157:H7
TLDR
Results suggest that yhiE and yhiF are involved in the adherence of O157Sakai to epithelial cells as negative regulators for the expression of the genes required for the type III secretion system. Expand
Complete nucleotide sequence of the prophage VT2-Sakai carrying the verotoxin 2 genes of the enterohemorrhagic Escherichia coli O157:H7 derived from the Sakai outbreak.
TLDR
The sequences in the regions of VT2-Sakai corresponding to the early gene regulators and replication proteins, and the DNA sequences recognized by the regulators share very limited homology to those of theVT2-encoding 933W phage carried by the EHEC O157:H7 strain EDL933 reported by Plunkett et al. Expand
Cardio-Ankle Vascular Index is Independently Associated with Future Cardiovascular Events in Outpatients with Metabolic Disorders.
TLDR
In individuals with metabolic disorders, CAVI was a predictor of future cardiovascular events, independent of traditional coronary risk factors, and is a potentially valuable tool to identify persons likely to benefit from more intensive therapeutic approaches. Expand
Geranylgeranylated Rho Small GTPase(s) Are Essential for the Degradation of p27Kip1 and Facilitate the Progression from G1 to S Phase in Growth-stimulated Rat FRTL-5 Cells*
TLDR
Among mevalonate metabolites, geranylgeranylated Rho small GTPase(s) promote the degradation of p27 during G1/S transition in FRTL-5 cells and are absolutely required for the elimination of p 27 followed by Cdk2 activation. Expand
PACAP Functions as a Neurotrophic Factor a
TLDR
Pituitary adenylate cyclase activating polypeptide (PACAP) was first isolated from ovine hypothalamic tissues during an attempt to isolate a novel hypophysiotropic hormone based on the ability to activate adenYLate Cyclase in rat pituitary cell cultures. Expand
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