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M2 muscarinic receptors on the iris sphincter muscle differ from those on iris noradrenergic nerves.
The pre- and postjunctional affinity constants of a series of muscarinic antagonists were determined in guinea pig and rabbit irises. Field stimulation-evoked [3H]noradrenaline release fromExpand
Muscarinic inhibition of [3H]‐noradrenaline release on rabbit iris in vitro: effects of stimulation conditions on intrinsic activity of methacholine and pilocarpine
1 Rabbit isolated irides were loaded with [3H]‐noradrenaline and superfused with Tyrode solution. The inhibition by the muscarinic agonists (±)‐methacholine and pilocarpine of the [3H]‐noradrenalineExpand
Effects of human recombinant interleukins on stimulation-evoked noradrenaline overflow from the rat perfused spleen
Experiments were carried out in the isolated spleen of the rat to study in a lymphoid organ the influence of interleukins (ILs) on noradrenaline release. Spleens were perfused with Tyrode's solutionExpand
Different muscarinic receptors mediate autoinhibition of acetylcholine release and vagally-induced vasoconstriction in the rat isolated perfused heart
SummaryExperiments were carried out on rat isolated perfused hearts with both vagus nerves attached. The acetylcholine stores were labelled with [14C]-choline. The effects of muscarinic receptorExpand
Alpha-adrenoceptor mediated facilitation of acetylcholine release in the rat perfused heart.
Rat hearts were isolated with the vagus nerves intact and perfused, and the neuronal acetylcholine stores were pulse labeled with [14C]choline. The overflow of [14C]choline/acetylcholine evoked byExpand
Muscarine receptor types mediating autoinhibition of acetylcholine release and sphincter contraction in the guinea-pig iris
SummaryThe potencies of several muscarine receptor antagonists in blocking either the autoinhibition of acetylcholine release or the muscarinic contraction of the sphincter muscle upon acetylcholineExpand
Influence of a receptor reserve on the inhibition by calcium channel blockers of alpha adrenoceptor-mediated responses in rat isolated vascular tissues.
The effects of the Ca entry blockers nifedipine and verapamil on the contractions induced by phenylephrine (PHE) in rat isolated aorta and mesenteric vascular bed (MVB) were evaluated. The main goalExpand
A muscarinic receptor different from the M1, M2, M3 and M4 subtypes mediates the contraction of the rabbit iris sphincter
SummaryIn order to analyse the subtype of muscarinic receptors involved in the methacholine-induced contraction of the rabbit iris sphincter we have determined equilibrium dissociation constants (KB)Expand
α1-antagonist activity of the α2-adrenoceptor agonist guanabenz in perfused mesenteric artery of the rat
Abstract In the perfused mesenteric artery of the rat phynylephrine produced a concentration-dependent increase in perfusion pressure which was competitively antagonized by low concentrations ofExpand
Inhibition by interleukin-1\ of noradrenaline release in rat spleen: involvement of lymphocytes, NO and opioid receptors
Effects of indomethacin, Nω-nitro-L-arginine (NNA) and naloxone, and of pretreatment with cyclophosphamide (CY), on the interleukin (IL)-I\ induced inhibition of exocytotic noradrenaline release wereExpand
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