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Muscarinic inhibition of [3H]‐noradrenaline release on rabbit iris in vitro: effects of stimulation conditions on intrinsic activity of methacholine and pilocarpine
TLDR
The results demonstrate a muscarinic inhibition of noradrenaline release from the rabbit isolated iris, and the activation by pilocarpine of the presynaptic receptors provides an alternative explanation for the miosis induced in the rabbit in vivo.
Effects of human recombinant interleukins on stimulation-evoked noradrenaline overflow from the rat perfused spleen
TLDR
The inhibitory effect of low concentrations of IL-1ß and IL-2 supports the idea that locally produced mediators of the immune system may affect neuronal function.
Different muscarinic receptors mediate autoinhibition of acetylcholine release and vagally-induced vasoconstriction in the rat isolated perfused heart
TLDR
The results show that the autoinhibition of acetylcholine release in the rat heart is mediated by M2 receptors and the increase in perfusion pressure upon vagus nerve stimulation is caused by a different muscarinic receptor, more sensitive to hexahydrosiladifenidol than to M2-selective antagonists.
Alpha-adrenoceptor mediated facilitation of acetylcholine release in the rat perfused heart.
TLDR
The results are compatible with an alpha-1 adrenoceptor-mediated facilitation of exocytotic acetylcholine release from the rat heart in vitro and the increase in evoked neurotransmitter overflow was not accompanied by an increase in postjunctional heart responses to vagus stimulation due to nonselective blocking properties of the facilitating agonists.
Muscarine receptor types mediating autoinhibition of acetylcholine release and sphincter contraction in the guinea-pig iris
TLDR
The results are consistent with the idea of M2 muscarine receptors mediating autoinhibition of acetylcholine release in the guinea-pig iris and M3-like receptors inducing the contraction of the sphincter muscle.
Influence of a receptor reserve on the inhibition by calcium channel blockers of alpha adrenoceptor-mediated responses in rat isolated vascular tissues.
TLDR
The effects of the Ca entry blockers nifedipine and verapamil on the contractions induced by phenylephrine in rat isolated aorta and mesenteric vascular bed were evaluated, suggesting receptor heterogeneity between the two tissues.
A muscarinic receptor different from the M1, M2, M3 and M4 subtypes mediates the contraction of the rabbit iris sphincter
TLDR
The muscarinic receptors in the rabbit iris sphincter may represent a novel type differing from M1–M4 receptors, suggesting receptor properties different from the presumed M5 receptor.
Inhibition by interleukin-1\ of noradrenaline release in rat spleen: involvement of lymphocytes, NO and opioid receptors
TLDR
The IL-1\ induced inhibition of evoked release appears to be a complex process which involves as one of many steps a decrease of the facilitatory NO-like compound and the release of endogenous opioids probably from spleen lymphocytes, compatible with the idea that in the rat spleen exocytotic noradrenaline release is accompanied by a concomitant secretion of a nitric oxide like compound.
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