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Pan-Cancer Analysis of the Mediator Complex Transcriptome Identifies CDK19 and CDK8 as Therapeutic Targets in Advanced Prostate Cancer
- J. Brägelmann, N. Klümper, +18 authors S. Perner
- Biology, Medicine
- Clinical Cancer Research
- 27 September 2016
Purpose: The Mediator complex is a multiprotein assembly, which serves as a hub for diverse signaling pathways to regulate gene expression. Because gene expression is frequently altered in cancer, a… Expand
The long non-coding RNA lnc-ZNF180-2 is a prognostic biomarker in patients with clear cell renal cell carcinoma.
- J. Ellinger, Jahedul Alam, +6 authors S. Müller
- American journal of cancer research
- 15 August 2015
Clear cell renal cell carcinoma (ccRCC) is among the most common human malignancies. Long non-coding RNAs (lncRNA) regulate various cellular functions and have been implicated in ccRCC pathogenesis.… Expand
Identification of novel long non-coding RNAs in clear cell renal cell carcinoma
BackgroundLong non-coding RNAs (lncRNA) play an important role in carcinogenesis; knowledge on lncRNA expression in renal cell carcinoma is rudimental. As a basis for biomarker development, we aimed… Expand
Circulating serum miRNA (miR-367-3p, miR-371a-3p, miR-372-3p and miR-373-3p) as biomarkers in patients with testicular germ cell cancer.
- I. Syring, J. Bartels, S. Holdenrieder, G. Kristiansen, S. Müller, J. Ellinger
- The Journal of urology
PURPOSE Classic serum tumor markers (human chorionic gonadotropin, α1-fetoprotein and lactate dehydrogenase) have an important role in managing testicular germ cell tumor. Since only 60% of all… Expand
Identification of the dopamine transporter SLC6A3 as a biomarker for patients with renal cell carcinoma
BackgroundClear cell renal cell carcinoma (ccRCC) is among the most common human malignancies.MethodsIn order to provide better understanding of the molecular biology of ccRCC and to identify… Expand
MED12 overexpression is a frequent event in castration-resistant prostate cancer.
In a recent effort to unravel the molecular basis of prostate cancer (PCa), Barbieri and colleagues using whole-exome sequencing identified a novel recurrently mutated gene, MED12, in 5.4% of primary… Expand
Influence of Body Mass Index on Clinical Outcome Parameters, Complication Rate and Survival after Radical Cystectomy: Evidence from a Prospective European Multicentre Study
Background/Aims/Objectives: To evaluate the influence of body mass index (BMI) on complications and oncological outcomes in patients undergoing radical cystectomy (RC). Methods: Clinical and… Expand
Reduction of Biofilm Formation on a‐C:H Coated Implants: Investigation of Biofilm‐Surface Interactions by Variation of Thin Film Properties
Formation of crystalline bacterial biofilms (encrustations) on urological implants remains a major complication in patient care. Recently, it was shown that amorphous carbon (a-C:H) coatings… Expand
Cell-Free SHOX2 DNA Methylation in Blood as a Molecular Staging Parameter for Risk Stratification in Renal Cell Carcinoma Patients: A Prospective Observational Cohort Study.
BACKGROUND Novel targeted treatments and immunotherapies have substantially changed therapeutic options for advanced and metastatic renal cell carcinomas (RCCs). However, accurate diagnostic tests… Expand
The long non-coding RNA lnc-ZNF 1802 is a prognostic biomarker in patients with clear cell renal cell carcinoma
Clear cell renal cell carcinoma (ccRCC) is among the most common human malignancies. Long noncoding RNAs (lncRNA) regulate various cellular functions and have been implicated in ccRCC pathogenesis.… Expand