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TOR controls translation initiation and early G1 progression in yeast.
- N. Barbet, U. Schneider, S. B. Helliwell, I. Stansfield, M. Tuite, M. Hall
- BiologyMolecular biology of the cell
It is proposed that the TORs, two related phosphatidylinositol kinase homologues, are part of a novel signaling pathway that activates eIF-4E-dependent protein synthesis and, thereby, G1 progression in response to nutrient availability and may constitute a checkpoint that prevents early G 1 progression and growth in the absence of nutrients.
Evolution of pathogenicity and sexual reproduction in eight Candida genomes
There are significant expansions of cell wall, secreted and transporter gene families in pathogenic species, suggesting adaptations associated with virulence in Candida albicans species.
Terminating eukaryote translation: domain 1 of release factor eRF1 functions in stop codon recognition.
The genetic screen results and the mutant phenotypes are consistent with a role for domain 1 in stop codon recognition; the topology of this e RF1 domain, together with eRF1-stop codon complex modeling further supports the proposal that this domain may represent the site of stop codons binding itself.
The products of the SUP45 (eRF1) and SUP35 genes interact to mediate translation termination in Saccharomyces cerevisiae.
It is proposed that Sup45p andSup35p interact to form a release factor complex in yeast and that Sup35p, which has GTP binding sequence motifs in its C‐terminal domain, provides the GTP hydrolytic activity which is a demonstrated requirement of the eukaryote translation termination reaction.
Endless possibilities: translation termination and stop codon recognition.
A review of recent advances in the use of optimized, complex, reconstituted in vitro termination reactions to identify the roles of key termination factors, and the solution of tertiary structures of termination factors has allowed a reappraisal of termination factor structure and function.
Ribosome Traffic on mRNAs Maps to Gene Ontology: Genome-wide Quantification of Translation Initiation Rates and Polysome Size Regulation
This analysis reveals that codon arrangement, rather than simply codon bias, has a key role in determining translational efficiency, and reveals that translation output is governed both by initiation efficiency and elongation dynamics.
Phylogenetic diversity of stress signalling pathways in fungi
- E. Nikolaou, I. Agrafioti, M. Stumpf, J. Quinn, I. Stansfield, Alistair J. P. Brown
- BiologyBMC Evolutionary Biology
- 21 February 2009
Comparing the conservation of stress signalling molecules in diverse fungal species with their stress resistance revealed that in general, central components of the osmotic, oxidative and cell wall stress signalling pathways are relatively well conserved, whereas the sensors lying upstream and transcriptional regulators lying downstream of these modules have diverged significantly.
Genome-wide prediction of stop codon readthrough during translation in the yeast Saccharomyces cerevisiae.
To identify novel contexts directing readthrough, under-represented 5' and 3' stop codon contexts from Saccharomyces cerevisiae were identified by genome-wide survey in silico, and a novel method analysing specific nucleotide combinations in the 3' context region revealed positions +1,2,3,5 and -1, 2, 3,6 after the stopcodon were most predictive of termination efficiency.
tRNA properties help shape codon pair preferences in open reading frames
Multivariate analysis identified conserved nucleotide positions within A-site tRNA sequences that modulate codon pair preferences and Structural features that regulate tRNA geometry within the ribosome may govern genomicCodon pair patterns, driving enhanced translational fidelity and/or rate.
A mutant allele of the SUP45 (SAL4) gene of Saccharomyces cerevisiae shows temperature-dependent allosuppressor and omnipotent suppressor phenotypes
Data indicate a role for Sup45p in translation termination, and possibly in an additional, as yet unidentified, cellular process, that contributes to the conditional-lethality conferred by the sal4-2 allele.