• Publications
  • Influence
Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome
  • Z. Reitman, G. Jin, +7 authors H. Yan
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 2 February 2011
Point mutations of the NADP+-dependent isocitrate dehydrogenases 1 and 2 (IDH1 and IDH2) occur early in the pathogenesis of gliomas. When mutated, IDH1 and IDH2 gain the ability to produce theExpand
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The SLCO1B1*5 genetic variant is associated with statin-induced side effects.
OBJECTIVES We sought to identify single nucleotide polymorphisms associated with mild statin-induced side effects. BACKGROUND Statin-induced side effects can interfere with therapy. SingleExpand
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Antihelminth compound niclosamide downregulates Wnt signaling and elicits antitumor responses in tumors with activating APC mutations.
Wnt/β-catenin pathway activation caused by adenomatous polyposis coli (APC) mutations occurs in approximately 80% of sporadic colorectal cancers (CRC). The antihelminth compound niclosamideExpand
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Phase I Trial of Doxorubicin-Containing Low Temperature Sensitive Liposomes in Spontaneous Canine Tumors
Purpose: To determine the maximum tolerated dose, dose-limiting toxicities, and pharmacokinetic characteristics of doxorubicin encapsulated in a low temperature sensitive liposome (LTSL) when givenExpand
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SOD therapeutics: latest insights into their structure-activity relationships and impact on the cellular redox-based signaling pathways.
SIGNIFICANCE Superoxide dismutase (SOD) enzymes are indispensable and ubiquitous antioxidant defenses maintaining the steady-state levels of O2·(-); no wonder, thus, that their mimics are remarkablyExpand
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A mouse-human phase 1 co-clinical trial of a protease-activated fluorescent probe for imaging cancer
A first-in-human phase 1 clinical trial of the PEGylated protease-activated fluorescent probe, LUM015, enables tumor imaging at a safe and tolerable dose in humans. Protease probe tested in humansExpand
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Bench-to-bedside review: Sepsis - from the redox point of view
The pathogenesis of sepsis and its progression to multiple organ dysfunction syndrome and septic shock have been the subject of investigations for nearly half a century. Controversies still existExpand
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Characterization of cell envelope‐associated proteinases of thermophilic lactobacilli
D. FIRA, M. KOJIC, A. BANINA, I. SPASOJEVIC, I. STRAHINIC AND L. TOPISIROVIC. 2001. The proteolytic activities of two natural isolates of thermophilic lactobacilli, Lactobacillus acidophilus BGRA43Expand
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Urinary biomarkers of oxidative status.
Oxidative damage produced by reactive oxygen species (ROS) has been implicated in the etiology and pathology of many health conditions, including a large number of chronic diseases. UrinaryExpand
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A joint analysis of metabolomics and genetics of breast cancer
IntroductionRemodeling of cellular metabolism appears to be a consequence and possibly a cause of oncogenic transformation in human cancers. Specific aspects of altered tumor metabolism may beExpand
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