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The podocyte's response to stress: the enigma of foot process effacement.
Progressive loss of podocytes is the most frequent cause accounting for end-stage renal failure. Podocytes are complex, terminally differentiated cells incapable of replicating. Thus lost podocytesExpand
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ECM Gene Expression and Its Modulation by Insulin in Diabetic Rats
The steady-state levels of mRNA encoding for the α1(IV) collagen chain, laminin B1 and B2 chains, basement membrane HSPG, and α1(I) and a1(III) collagen chains were examined in rat glomeruli at 4,Expand
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Selective accumulation of CCR4+ T lymphocytes into renal tissue of patients with lupus nephritis.
OBJECTIVE Some chemokine receptors, such as CCR5 and CCR4, are differentially expressed on Th1 and Th2 cells. To determine whether differential expression of the chemokine receptors occurs inExpand
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Podocyte Migration during Nephrotic Syndrome Requires a Coordinated Interplay between Cathepsin L and α3 Integrin*
Podocyte foot process effacement and disruption of the slit diaphragm are typically associated with glomerular proteinuria and can be induced in rats by the injection of puromycin aminonucleoside.Expand
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Cytoskeletal changes in podocytes associated with foot process effacement in Masugi nephritis.
Foot process effacement represents the most characteristic change in podocyte phenotype under a great variety of experimental as well as human glomerulopathies. It consists in simplification up to aExpand
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MAP‐LC3, a promising autophagosomal marker, is processed during the differentiation and recovery of podocytes from PAN nephrosis
Microtubule‐associated protein 1 light chain 3 (LC3) is a unique modifier protein. LC3‐I, the cytosolic form, is modified to LC3‐II, the membrane‐bound form, by a mechanism similar to ubiquitylationExpand
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The development of focal segmental glomerulosclerosis in Masugi nephritis is based on progressive podocyte damage
We analysed the sequence of structural changes leading to focal segmental glomerulosclerosis (FSGS) in chronic Masugi nephritis. The protocol resulted in an immediate onset of the disease and theExpand
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Effects Of The New Hydroxy‐3‐Methylglutaryl Coenzyme A Reductase Inhibitor Fluvastatin On Anti‐Oxidant Enzyme Activities And Renal Function In Streptozotocin‐Induced Diabetic Rats
1. The effects of 11 week treatments with the new hydroxy‐3‐methylglutaryl coenzyme A (HMG‐CoA) reductase inhibitor fluvastatin on renal intrinsic anti‐oxidant enzyme (AOE) activities and renalExpand
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Fine structure of the glomerular basement membrane of the rat kidney visualized by high-resolution scanning electron microscopy
SummaryThe fine structure of the glomerular basement membrane (GBM) of the rat kidney was studied by means of high resolution scanning electron microscopy. Specimens were taken from kidneys perfusedExpand
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Location and action of angiotensin II type 1 receptor in the renal microcirculation.
To localize angiotensin II type 1a (AT-1a) receptor and to reveal the physiological roles of angiotensin II in the renal microcirculation, we investigated the AT-1a gene deficient mice, generated byExpand
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