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PLA2G6 mutation underlies infantile neuroaxonal dystrophy.
Infantile neuroaxonal dystrophy (INAD) is an autosomal recessive progressive neurodegenerative disease that presents within the first 2 years of life and culminates in death by age 10 years. AffectedExpand
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Anatomy and physiology of the blood-brain barrier.
Essential requisite for the preservation of normal brain activity is to maintain a narrow and stable homeostatic control in the neuronal environment of the CNS. Blood flow alterations and alteredExpand
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Blood-Brain Barrier Breakdown Following Traumatic Brain Injury: A Possible Role in Posttraumatic Epilepsy
Recent animal experiments indicate a critical role for opening of the blood-brain barrier (BBB) in the pathogenesis of post-traumatic epilepsy (PTE). This study aimed to investigate the frequency,Expand
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Recording, analysis, and interpretation of spreading depolarizations in neurointensive care: Review and recommendations of the COSBID research group
Spreading depolarizations (SD) are waves of abrupt, near-complete breakdown of neuronal transmembrane ion gradients, are the largest possible pathophysiologic disruption of viable cerebral grayExpand
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Effects of Initiating Moderate Alcohol Intake on Cardiometabolic Risk in Adults With Type 2 Diabetes: A 2-Year Randomized, Controlled Trial.
BACKGROUND Recommendations for moderate alcohol consumption remain controversial, particularly in type 2 diabetes mellitus (T2DM). Long-term randomized, controlled trials (RCTs) are lacking. Expand
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Interleukin-1β Regulates Fat-Liver Crosstalk in Obesity by Auto-Paracrine Modulation of Adipose Tissue Inflammation and Expandability
The inflammasome has been recently implicated in obesity-associated dys-metabolism. However, of its products, the specific role of IL-1β was clinically demonstrated to mediate only the pancreaticExpand
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Imaging blood-brain barrier dysfunction in football players.
Imaging Blood-Brain Barrier Dysfunction in Football Players There has been an increasing awareness of the long-term neuropsychiatric pathologies associated with repeated mild traumatic brain injuryExpand
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Three‐Dimensional Representations of Objects in Dorsal Cortex are Dissociable from Those in Ventral Cortex
Abstract An established conceptualization of visual cortical function is one in which ventral regions mediate object perception while dorsal regions support spatial information processing andExpand
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β-Alanine ingestion increases muscle carnosine content and combat specific performance in soldiers
The purpose of this study was to examine the effect of β-alanine (BA) ingestion on tissue carnosine levels and the impact such changes would have on combat specific activity. Eighteen soldiers (19.9Expand
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Blood–brain barrier disruption in post-traumatic epilepsy
Background: Traumatic brain injury (TBI) is an important cause of focal epilepsy. Animal experiments indicate that disruption of the blood–brain barrier (BBB) plays a critical role in theExpand
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