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Vitamin D: beyond bone
In recent years, vitamin D has been received increased attention due to the resurgence of vitamin D deficiency and rickets in developed countries and the identification of extraskeletal effects ofExpand
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Nongenomic actions of 1,25-dihydroxyvitamin D3 in rat osteosarcoma cells: structure-function studies using ligand analogs.
Osteoblast-like osteosarcoma cells (ROS 17/2.8) display a rapid transmembrane influx of extracellular calcium after stimulation by 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] that is mediated largely byExpand
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Calcium and vitamin D in obesity.
New and more effective nutritional measures are urgently needed for the prevention of obesity. The role of Ca and vitamin D in obesity has been recently implicated. Low Ca intake and low vitamin DExpand
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Calcium and Calpain as Key Mediators of Apoptosis-like Death Induced by Vitamin D Compounds in Breast Cancer Cells*
The active form of vitamin D3 (1,25(OH)2D3) induces an increase in the intracellular free calcium ([Ca2+] i ) and caspase-independent cell death in human breast cancer cells. Here we show that theExpand
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High vitamin D and calcium intakes reduce diet-induced obesity in mice by increasing adipose tissue apoptosis.
SCOPE Modulation of apoptosis is emerging as a promising antiobesity strategy because removal of adipocytes through this process will result in reducing body fat. Effects of vitamin D on apoptosisExpand
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Oxidative stress inhibits the mitochondrial import of preproteins and leads to their degradation.
The mitochondrion depends upon the import of cytosolically synthesized preproteins for most of the proteins that comprise its structural elements and metabolic pathways. Here we have examined theExpand
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Genistein induces Ca2+ -mediated, calpain/caspase-12-dependent apoptosis in breast cancer cells.
  • I. Sergeev
  • Biology, Medicine
  • Biochemical and biophysical research…
  • 20 August 2004
Genistein, a soy-derived isoflavone, has been suggested for breast cancer prevention; however, use of soy products for this purpose remains controversial. Genistein has been reported to regulateExpand
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Calcium signaling in cancer and vitamin D
  • I. Sergeev
  • Biology, Medicine
  • The Journal of Steroid Biochemistry and Molecular…
  • 1 October 2005
Calcium signals induced by the Ca(2+) regulatory hormone 1,25(OH)(2)D(3) may determine the fate of the cancer cell. We have shown that, in breast cancer cell lines, 1,25(OH)(2)D(3) induces aExpand
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Apoptosis-inducing activity of hydroxylated polymethoxyflavones and polymethoxyflavones from orange peel in human breast cancer cells.
Sweet orange (Citrus sinensis L.) peel is a rich resource of flavonoids, especially polymethoxyflavones (PMFs). Citrus flavonoids exert a broad spectrum of biological activity, includingExpand
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Calcium as a mediator of apoptosis in bovine oocytes and preimplantation embryos
Cell death pathways and their regulation during development of the preimplantation embryo are poorly understood. Our previous studies indicate that Ca2+ is a key mediator of apoptosis in differentExpand
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