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Cardiac troponin T release and inflammation demonstrated in marathon runners.
Mild inflammation is evidently one of the events contributing to the cardiac troponin release under conditions suggested as unrelated to irreversible cardiac alteration, as demonstrated after physiological heart stress such as marathon running. Expand
Transgenic activation of the kallikrein‐kinin system inhibits intramyocardial inflammation, endothelial dysfunction, and oxidative stress in experimental diabetic cardiomyopathy
- C. Tschöpe, T. Walther, +8 authors And Michel Noutsias
- FASEB journal : official publication of the…
- 1 December 2005
The multiple protective effects of the KKS in experimental diabetic cardiomyopathy comprise the inhibition of intramyocardial inflammation, an improvement of endothelium‐dependent relaxation and the attenuation of oxidative stress. Expand
Cardiac and renal function in a large cohort of amateur marathon runners
The increase in cardiac biomarkers after completing a marathon was not accompanied by relevant cardiac dysfunction as assessed by echocardiography, and all cardiac and renal parameters returned to baseline ranges within 2 weeks after the marathon. Expand
*NO and oxyradical metabolism in new cell lines of rat brain capillary endothelial cells forming the blood-brain barrier.
Comparing the cell lines obtained, rBCEC4 are stable immortalized and reveal the best conservation of properties from primary cells, including enzymes producing or decomposing reactive species. Expand
Abundance and location of the small heat shock proteins HSP25 and alphaB-crystallin in rat and human heart.
Differential accumulation and location of HSP25 and alphaB-crystallin in heart tissue during development imply distinct functions of both proteins, which seem to be involved in organization of cytoskeletal structures. Expand
Impaired ventilatory efficiency in chronic heart failure: possible role of pulmonary vasoconstriction.
Impairment of ventilatory efficiency in chronic heart failure is correlated with resting pulmonary artery pressures and associated with the impairment of exercise capacity, suggesting an imbalance of pulmonary vascular tone probably leads to both pulmonary hypertension and alveolar hypoperfusion. Expand
Agonistic autoantibodies directed against G-protein-coupled receptors and their relationship to cardiovascular diseases
The present knowledge about GPCR-AABs in cardiovascular diseases is summarized and treatment strategies that are currently under study, most of which are aimed at the removal and in vivo neutralization of G-protein-coupled receptor (GPCR) are indicated and their patient benefits discussed. Expand
Distinct patterns of autoantibodies against G-protein-coupled receptors in Chagas' cardiomyopathy and megacolon. Their potential impact for early risk assessment in asymptomatic Chagas' patients.
- G. Wallukat, Silvia Gilka Muñoz Saravia, +7 authors I. Schimke
- Journal of the American College of Cardiology
- 2 February 2010
It is hypothesized that beta1-, beta2-, and M2-AAB measurement might be a useful tool for risk assessment in the indeterminate state of Chagas' disease to select patients for earlier involvement in care programs. Expand
Quality and timeliness in medical laboratory testing
- I. Schimke
- Computer Science, Medicine
- Analytical and bioanalytical chemistry
- 1 March 2009
POCT should not replace centralized medical laboratory testing in general, but it should be used in cases where positive effects on patient care have been clearly demonstrated, and when the central laboratory cannot guarantee the delivery of results of short turn-around-time (STAT) markers within 60 or (even better) 30 min. Expand
Antihypertensive effect of 0.1-Hz blood pressure oscillations to the kidney.
BP fluctuations transiently stimulate NO liberation and induce a reduction in PRA, which enhances 24-hour sodium and water excretion and markedly attenuates the acute development of renovascular hypertension. Expand