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Type II Cadherin Ectodomain Structures: Implications for Classical Cadherin Specificity
Type I and II classical cadherins help to determine the adhesive specificities of animal cells. Crystal-structure determination of ectodomain regions from three type II cadherins reveals adhesiveExpand
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Single-cell topological RNA-Seq analysis reveals insights into cellular differentiation and development
Transcriptional programs control cellular lineage commitment and differentiation during development. Understanding of cell fate has been advanced by studying single-cell RNA-sequencing (RNA-seq) butExpand
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P2Z adenosine triphosphate receptor activity in cultured human monocyte-derived macrophages.
The present study shows that human mononuclear phagocytes express a P2Z-like purinergic membrane receptor activity. Extracellular adenosine triphosphate (ATP) induces the formation of nonselectiveExpand
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Mice deficient in Abl are osteoporotic and have defects in osteoblast maturation
The c-Abl protein is a non-receptor tyrosine kinase involved in many aspects of mammalian development. c-Abl kinase is widely expressed, but high levels are found in hyaline cartilage in the adult,Expand
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Linking protein kinase C to the cell cycle: ectopic expression of PKC eta in NIH3T3 cells alters the expression of cyclins and Cdk inhibitors and induces adipogenesis.
Protein kinase C encodes a family of enzymes implicated in cellular differentiation, growth control and tumor promotion. However, very little is known with respect to the molecular mechanisms thatExpand
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Impact of D2 Receptor Internalization on Binding Affinity of Neuroimaging Radiotracers
Synaptic dopamine (DA) levels seem to affect the in vivo binding of many D2 receptor radioligands. Thus, release of endogenous DA induced by the administration of amphetamine decreases ligandExpand
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Antisense to cyclin D1 inhibits growth and reverses the transformed phenotype of human esophageal cancer cells.
The cyclin D1 gene is amplified and overexpressed in a significant fraction of human esophageal tumors, and several other types of human cancer, but the functional significance of this overexpressionExpand
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Paradoxical increase in retinoblastoma protein in colorectal carcinomas may protect cells from apoptosis.
The retinoblastoma (Rb) gene is inactivated in a variety of human cancers, but in colorectal carcinomas there is frequently increased expression of this gene. This is paradoxical in view of the knownExpand
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Optimization of protein production in mammalian cells with a coexpressed fluorescent marker.
The expression of mammalian proteins in sufficient abundance and quality for structural studies often presents formidable challenges. Many express poorly in bacterial systems, whereas it can be timeExpand
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Overexpression of cyclin E in the HC11 mouse mammary epithelial cell line is associated with growth inhibition and increased expression of p27(Kip1).
To elucidate the role of cyclin E in cell growth and tumorigenesis in mammary epithelial cells, we have used retrovirus-mediated transduction to generate derivatives of the nontransformed HC11 mouseExpand
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