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Nutrigenomics: a case for the common soil between cardiovascular disease and cancer
The border between health and disease is often set by a complex equilibrium between two elements, genetics on one hand, lifestyle on the other, To know it better, means to give new weapons, oftenExpand
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White blood cells count , sex and age are major determinants of platelet indices heterogeneity in an adult general population : results from the MOLI-SANI project by
Publisher's Disclaimer. E-publishing ahead of print is increasingly important for the rapid dissemination of science. Haematologica is, therefore, E-publishing PDF files of an early version ofExpand
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From candidate gene to genome-wide association studies in cardiovascular disease.
Continuous updating of the genotyping technology has led to improvement of genetic study design. The recent advances in technology coupled with the advances in our understanding of the molecularExpand
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Phosphorylation of huntingtin at residue T3 is decreased in Huntington’s disease and modulates mutant huntingtin protein conformation
Significance The findings in this manuscript report on the identification of a posttranslational modification in the huntingtin protein (phosphorylation on residue T3 in the N17 region of theExpand
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Polyglutamine expansion affects huntingtin conformation in multiple Huntington’s disease models
Conformational changes in disease-associated or mutant proteins represent a key pathological aspect of Huntington’s disease (HD) and other protein misfolding diseases. Using immunoassays andExpand
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Variability of platelet indices and function: acquired and genetic factors.
Each individual has an inherent variable risk of bleeding linked to genetic or acquired abnormal platelet number or platelet dysfunction. In contrast, it is less obvious that the variability ofExpand
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Generation of induced pluripotent stem cell line, CSSi002-A (2851), from a patient with juvenile Huntington Disease.
Huntington Disease (HD) is an autosomal dominant disorder characterized by motor, cognitive and behavioral features caused by a CAG expansion in the HTT gene beyond 35 repeats. The juvenile formExpand
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Generation of induced pluripotent stem cell line, CSSi004-A (2962), from a patient diagnosed with Huntington's disease at the presymptomatic stage.
Huntington's disease (HD) is an incurable, autosomal dominant, hereditary neurodegenerative disorder that typically manifests itself in midlife. This pathology is linked to the deregulation ofExpand
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Nutrigénomique: cas pour un terrain commun à la maladie cardiovasculaire et au cancer
RésuméLa limite entre la santé et la maladie est souvent établie par un équilibre complexe entre deux éléments, génétique d’une part et style de vie de l’autre. Mieux le comprendre signifie mettre deExpand