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Differential expression of peroxisome proliferator-activated receptor subtypes during the differentiation of human keratinocytes.
TLDR
The expression of mRNA encoding peroxisome proliferator-activated receptor (PPAR) subtypes in human keratinocytes was determined by semiquantitative reverse transcriptase-polymerase chain reaction and it was found that these two subtypes are tightly linked to the epidermal differentiation process. Expand
Regulation by fatty acids of angiotensinogen gene expression in preadipose cells.
TLDR
The AT gene appears to be a fatty acid-responsive gene; this regulation provides a potential link between the flux of fatty acids and the potential of adipose tissue to produce AT and possibly A-II. Expand
Retinoids are positive effectors of adipose cell differentiation
TLDR
It is shown that, when present at concentrations below or close to the Kd values of retinoic acid receptors, retinoids behave as potent adipogenic hormones (1 pM to 10 nM range) and, by the use of specific ligands for each RAR subtype, these positive effects on adipose differentiation involve in particular the RAR alpha subtype. Expand
Regulation by glucocorticoids of angiotensinogen gene expression and secretion in adipose cells.
TLDR
Together these results provide a potential link between glucocorticoids, AT, the growth of adipose tissue and increased blood pressure. Expand
Peroxisome proliferator-activated receptor-alpha enhances lipid metabolism in a skin equivalent model.
TLDR
Results show that peroxisome proliferator-activated receptor-alpha is a key transcription factor involved in the control of the epidermal lipid barrier. Expand
Differential Expression of Peroxisome Proliferator-Activated Receptor Subtypes During the Differentiation of Human Keratinocytes
TLDR
The expression of mRNA encoding peroxisome proliferator-activated receptor (PPAR) subtypes in human keratinocytes was determined by semiquantitative reverse transcriptase-polymerase chain reaction and reduced, indicating that these two subtypes are tightly linked to the epidermal differentiation process. Expand
Insulin down-regulates angiotensinogen gene expression and angiotensinogen secretion in cultured adipose cells.
TLDR
It is suggested that a potential link between insulin resistance and high blood pressure may exist by means of increased AT secretion from adipose tissue, especially in obese subjects. Expand
Epidermal anti-Inflammatory properties of 5,11,14 20:3: Effects on mouse ear edema, PGE2 levels in cultured keratinocytes, and PPAR activation
TLDR
Topical application of 5,11,14 20:3 to skin surfaces can reduce inflammatory processes, most likely by displacing 20:4n-6 from phospholipid pools and reducing downstream inflammatory products derived from 20: 4n- 6 such as PGE2 and leukotrienes. Expand
Fatty acids and retinoids act synergistically on adipose cell differentiation.
TLDR
Treatment of Ob1771 preadipose cells with selective agonists of retinoic acid receptors (RARs) in the presence of alpha-bromopalmitate led to a potent synergy in regard to the differentiation process, as assayed by the activity of glycerol-3-phosphate dehydrogenase. Expand
Effect of the physicochemical parameters of benzimidazole molecules on their retention by a nonpolar sorbent from an aqueous acetonitrile solution
The effect of the structure of benzimidazoles on their chromatographic retention on octadecyl silica gel from an aqueous acetonitrile eluent was studied. One- and many-parameter correlation equationsExpand
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