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Nitroglycerin Tolerance in Human Vessels: Evidence for Impaired Nitroglycerin Bioconversion
TLDR
NTG tolerance in patients with coronary artery disease is nitrate-specific and is associated with evidence of impaired NTG bioconversion, and tolerance was associated with incremental O2– generation, but short-term elevation of O1– did not affect NTG responsiveness, suggesting increased NO clearance by O2- has a minimal contribution to tolerance. Expand
A simple isolated nerve-blood vessel preparation.
Log-normal distribution of equiefective doses of norepinephrine and acetylcholine in several tissues.
TLDR
It is concluded that the distribution of equieffective doses of agonists is generally normal on a log scale but not on an arithmetic scale, and the means of equies and the statistical tests of their significance should be based on mean logs or their antilogs, the geometric means, not on arithmetic means. Expand
The interaction of serotonin and noradrenaline on the perfused artery.
Phospholipase A in the venom of the Australian bulldog ant Myrmecia pyriformis.
TLDR
The fatty acid distribution in the hydrolysis products after incubation of the ant venom with liver lecithin with different fatty acid composition at the 1- and 2-positions was the same as after incubating with a purified snake venom phospholipase A preparation. Expand
The effect of antagonists on the response of the forearm vessels to adrenaline
TLDR
Evidence is presented in this paper that the responses of the forearm vessels to adrenaline represent a balance of constrictor and dilator effects. Expand
MODIFICATION OF AUTOFLUORESCENCE IN THE FORMALDEHYDE-TREATED RABBIT EAR ARTERY BY EVANS BLUE
TLDR
It is interesting that deoxyribonumcleic acid in Feulgen preparations stained deep blue imistead of the brown-violet color of bemizaldehyde-Schiff derivative and PAS-stained cellulose or mucin, which suggests some kind of chemical equilibrium in the altered molecule. Expand
Aldehyde dehydrogenase, nitric oxide synthase and superoxide in ex vivo nitrate tolerance in rat aorta.
TLDR
The discrepancies are consistent with evidence that (a) organic nitrates, unlike chloral and cyanamide, irreversibly inactivate ALDH (hence reduced enzyme saturability can explain the biphasic curve) and eNOS contributes to tolerance by a mechanism independent of glyceryl trinitrate metabolism. Expand
Uptake and O-methylation of isoprenaline in the rabbit ear artery.
TLDR
O-methylation in the intact artery is a saturable process which serves to limit the accumulation of 3HISO when the bathing concentration of the amine is low, and deoxycorticosterone acetate exerts its effects by inhibiting extraneuronal uptake into the compartment possessing O-methylating activity. Expand
Evidence for presynaptic cholinergic receptors in sympathetic nerves in human dental pulp.
TLDR
It was concluded that sympathetic nerves in human dental pulp possess (a) presynaptic muscarinic receptors that inhibit the SI release of noradrenaline, and (b) nicotinic receptors that evoke the release of Noradrenalin and that inhibits theSI release of the transmitter. Expand
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