I. S. K. Gardner

Sort by:

Design of ester prodrugs to enhance oral absorption of poorly permeable compounds: challenges to the discovery scientist.

Kevin C Beaumont, Robert Webster, I. S. K. Gardner, Kevin N Dack
Current drug metabolism
2003

Many drugs are administered at sites that are remote from their site of action. The most common route of drug delivery is the oral route. The optimal physicochemical properties to allow high… (More)

Cytochrome P450 mediated bioactivation of methyleugenol to 1'-hydroxymethyleugenol in Fischer 344 rat and human liver microsomes.

I. S. K. Gardner, H Wakazono, +4 authors John Caldwell
Carcinogenesis
1997

Cytochrome P450 mediated metabolism of methyleugenol to the proximate carcinogen 1'-hydroxymethyleugenol has been investigated in vitro. Kinetic studies undertaken in liver microsomes from control… (More)

A comprehensive listing of bioactivation pathways of organic functional groups.

Amit S Kalgutkar, I. S. K. Gardner, +10 authors Shawn P Harriman
Current drug metabolism
2005

The occurrence of idiosyncratic adverse drug reactions during late clinical trials or after a drug has been released can lead to a severe restriction in its use and even in its withdrawal. Metabolic… (More)

Isolation of a human T-lymphotropic virus type I strain from Australian aboriginals.

Ivan Bastian, Jimmy Gardner, Dennis Webb, I. S. K. Gardner
Journal of virology
1993

A human T-lymphotropic virus type I (HTLV-I) strain was isolated in a CD4+ T-lymphocyte culture established from a healthy seropositive Australian Aboriginal. This isolate, identified as… (More)

Prediction of Drug-Drug Interactions Arising from CYP3A induction Using a Physiologically Based Dynamic Model

Lisa M. Almond, Sophie Mukadam, +8 authors Jane R. Kenny
Drug metabolism and disposition: the biological…
2016

Using physiologically based pharmacokinetic modeling, we predicted the magnitude of drug-drug interactions (DDIs) for studies with rifampicin and seven CYP3A4 probe substrates administered i.v. (10… (More)

Cytochrome P 450 mediated bioactivation of methyleugenol to 1 9-hydroxymethyleugenol in Fischer 344 rat and human liver microsomes

I. S. K. Gardner, Hiroshi Wakazono, +4 authors John Caldwell
1997

cytochrome P450 enzyme system (3). The 1 9-hydroxy metabolCytochrome P450 mediated metabolism of methyleugenol ites are then sulfated, yielding 1 9-sulfooxy metabolites (4) to the proximate… (More)

Pharmacokinetics, pharmacodynamics and physiologically-based pharmacokinetic modelling of monoclonal antibodies.

Miroslav Dostalek, I. S. K. Gardner, Brian M. Gurbaxani, Rachel H. Rose, Manoranjenni Chetty
Clinical pharmacokinetics
2013

Development of monoclonal antibodies (mAbs) and their functional derivatives represents a growing segment of the development pipeline in the pharmaceutical industry. More than 25 mAbs and derivatives… (More)

Zebrafish based assays for the assessment of cardiac, visual and gut function--potential safety screens for early drug discovery.

Stéphane Berghmans, Paul Butler, +8 authors Angeleen Fleming
Journal of pharmacological and toxicological…
2008

INTRODUCTION Safety pharmacology is integral to the non-clinical safety assessment of new chemical entities prior to first administration to humans. The zebrafish is a well established model organism… (More)

A physiologically based pharmacokinetic modeling approach to predict disease-drug interactions: suppression of CYP3A by IL-6.

Krishna K Machavaram, Lisa M. Almond, +6 authors Jane R. Kenny
Clinical pharmacology and therapeutics
2013

Elevated cytokine levels are known to downregulate expression and suppress activity of cytochrome P450 enzymes (CYPs). Cytokine-modulating therapeutic proteins (TPs) used in the treatment of… (More)

Are endosomal trafficking parameters better targets for improving mAb pharmacokinetics than FcRn binding affinity?

Brian M. Gurbaxani, Miroslav Dostalek, I. S. K. Gardner
Molecular immunology
2013

F.W.R. Brambell deduced the existence of a protective receptor for IgG, the neonatal Fc receptor (FcRn), long before its discovery in the early to mid-1990s. With the coincident, explosive… (More)

Filter Results:

Publication Year

Publication Type

Co-author

Journals and Conferences