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Genetic Variants of the Organic Cation Transporter 2 Influence the Disposition of Metformin
- I. Song, H. J. Shin, +4 authors J. G. Shin
- Chemistry, Medicine
- Clinical pharmacology and therapeutics
- 1 November 2008
Genetic variants of the organic cation transporter 2 (protein, OCT2; gene, SLC22A2) were evaluated for their contribution to the variations in the pharmacokinetics of metformin, especially to its… Expand
Acidic polysaccharide from Panax ginseng, ginsan, induces Th1 cell and macrophage cytokines and generates LAK cells in synergy with rIL-2.
We previously reported that an acidic polysaccharide from Panax ginseng named ginsan inhibits the incidence of benzo[a]pyrene-induced autochthonous lung tumors in mice. To elucidate the mechanism of… Expand
Anti-septicaemic effect of polysaccharide from Panax ginseng by macrophage activation.
- D. Lim, K. G. Bae, I. S. Jung, C. H. Kim, Y. Yun, J. Y. Song
- Biology, Medicine
- The Journal of infection
- 1 July 2002
The aim of the present research was conducted to elucidate anti-septicaemic effect of a polysaccharide (PS) isolated from Panax ginseng C.A. Meyer (Araliaceae) by nitric oxide production from… Expand
Effect of nitric oxide synthase inhibitor and NMDA receptor antagonist on the development of nicotine sensitization of nucleus accumbens dopamine release: An in vivo microdialysis study
We have previously found that the neuronal nitric oxide synthase inhibitor N-nitro-L-arginine (L-NNA) and the noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist MK-801 prevent behavioral… Expand
Recognition of Advance Directives by Advanced Cancer Patients and Medical Doctors in Hospice Care Ward
Purpose: We undertook this study to find out the recognitions of termina l cancer patients and doctors about advance directives (ADs), of how they would do in non-response medical conditions and… Expand
Inhibition of autochthonous tumor by ethanol insoluble fraction from Panax ginseng as an immunomodulator.
The water extract of Panax ginseng was fractionated by its solubility in ethanol and then the ethanol-insoluble fraction was tested for immunomodulatory activity. The ethanol-insoluble fraction of… Expand
Proof of mechanism study of a novel serotonin transporter blocker, DA-8031, using [11C]DASB positron emission tomography and in vivo microdialysis.
OBJECTIVE To investigate the efficacy of DA-8031, a novel compound for the treatment of premature ejaculation, we measured serotonin transporter (SERT) occupancy by DA-8031, as well as… Expand
PET imaging of dopamine transporters with [(18)F]FE-PE2I: Effects of anti-Parkinsonian drugs.
- Ji-In Bang, I. S. Jung, +4 authors S. Kim
- Medicine, Chemistry
- Nuclear medicine and biology
- 1 February 2016
PURPOSE This study aimed to assess the striatal [(18)F]FE-PE2I binding and the immunohistochemical stain of tyrosine hydroxylase (TH) in the striatum, and to evaluate the effects of therapeutic drugs… Expand
Androgen Receptor Gene Mutation Associated with Complete Androgen Insensitivity Syndrome and Sertoli Cell Adenoma
- H. M. Ko, J. Chung, +4 authors C. Choi
- Biology, Medicine
- International journal of gynecological pathology…
- 1 April 2001
We report a case of Sertoli cell adenoma in complete androgen insensitivity syndrome (CAIS) in a 22-year-old woman. Polymerase chain reaction-single strand conformation polymorphism and DNA… Expand
A Case of Recalcitrant Erythema Nodosum Associated with Pancreatic Cancer
Vol. 31, N o. 6, 2019 685 Received March 13, 2019, Revised May 7, 2019, Accepted for publication June 1, 2019 Corresponding author: Young Ho Won, Department of Dermatology, Chonnam National… Expand