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The YEASTRACT database: an upgraded information system for the analysis of gene and genomic transcription regulation in Saccharomyces cerevisiae
- Miguel C. Teixeira, Pedro T. Monteiro, +11 authors I. Sá-Correia
- Biology, Computer ScienceNucleic Acids Res.
- 28 October 2013
The YEASTRACT information system was revisited and new information was added on the experimental conditions in which those associations take place and on whether the TF is acting on its target genes as activator or repressor, allowing the selection of specific environmental conditions, experimental evidence or positive/negative regulatory effect.
Genome-wide identification of Saccharomyces cerevisiae genes required for tolerance to acetic acid
- N. Mira, M. Palma, J. Guerreiro, I. Sá-Correia
- Biology, MedicineMicrobial cell factories
- 25 October 2010
The increase of potassium concentration in the growth medium was found to improve the expression of maximal tolerance to acetic acid, consistent with the idea that the adequate manipulation of nutrient concentration of industrial growth medium can be an interesting strategy to surpass the deleterious effects of this weak acid in yeast cells.
Identification of Regulatory Modules in Time Series Gene Expression Data Using a Linear Time Biclustering Algorithm
- S. Madeira, Miguel C. Teixeira, I. Sá-Correia, A.L. Oliveira
- Computer Science, MedicineIEEE/ACM Transactions on Computational Biology…
Results obtained using the transcriptomic expression patterns occurring in Saccharomyces cerevisiae in response to heat stress show the ability of the proposed methodology to extract relevant information compatible with documented biological knowledge but also the utility of using this algorithm in the study of other environmental stresses and of regulatory modules in general.
Saccharomyces cerevisiae adaptation to weak acids involves the transcription factor Haa1p and Haa1p-regulated genes.
- A. R. Fernandes, N. Mira, R. C. Vargas, I. Canelhas, I. Sá-Correia
- Biology, MedicineBiochemical and biophysical research…
- 11 November 2005
The acetic acid-induced prolongation of the lag phase of unadapted cell populations lacking HAA1 or TPO3, compared with wild-type population, was correlated with the level of the acid accumulated into the stressed cells.
YEASTRACT-DISCOVERER: new tools to improve the analysis of transcriptional regulatory associations in Saccharomyces cerevisiae
- Pedro T. Monteiro, N. Mendes, +10 authors A. T. Freitas
- Biology, MedicineNucleic Acids Res.
- 21 November 2007
The Yeast search for transcriptional regulators and consensus tracking (YEASTRACT) information system was developed to support the analysis of transcription regulatory associations in Saccharomyces cerevisiae and includes DISCOVERER, a set of computational tools that can be used to identify complex motifs over-represented in the promoter regions of co-regulated genes.
Genomic expression program involving the Haa1p-regulon in Saccharomyces cerevisiae response to acetic acid.
- N. Mira, J. Becker, I. Sá-Correia
- Biology, MedicineOmics : a journal of integrative biology
- 18 October 2010
The deletion of the HRK1 gene was found to lead to the increase of the accumulation of labeled acetic acid into acid-stressed yeast cells, suggesting that the role of both HAA1 andHRK1 in providing protection against acetic Acid is, at least partially, related with their involvement in the reduction of intracellular acetate concentration.
Occurrence, production, and applications of gellan: current state and perspectives
- A. Fialho, L. M. Moreira, A. Granja, A. Popescu, K. Hoffmann, I. Sá-Correia
- Chemistry, MedicineApplied Microbiology and Biotechnology
- 28 May 2008
This review summarizes current knowledge on the structure and properties of gellan and provides details about the biosynthesis of this exopolysaccharide.
The Pht1;9 and Pht1;8 transporters mediate inorganic phosphate acquisition by the Arabidopsis thaliana root during phosphorus starvation.
- E. Remy, T. R. Cabrito, R. A. Batista, Miguel C. Teixeira, I. Sá-Correia, P. Duque
- Biology, MedicineThe New phytologist
- 1 July 2012
Pht1;9 encodes a functional plasma membrane-localized transporter that mediates high-affinity Pi/H⁺ symport activity in yeast and is highly induced in Pi-starved Arabidopsis roots, indicating that both the Pht 1;9 and Pht2;8 transporters function in sustaining plant Pi supply on environmental Pi depletion.
Combined bioaugmentation and biostimulation to cleanup soil contaminated with high concentrations of atrazine.
- Elisabete Silva, A. Fialho, I. Sá-Correia, R. Burns, L. Shaw
- Chemistry, MedicineEnvironmental science & technology
- 15 January 2004
A critical parameter in determining the extent of atrazine mineralization by P. ADP was C(s):N(atz) (soluble carbon toAtrazine nitrogen ratio): C(a) > 40 was required for maximal atrazin mineralization.
Dtr1p, a Multidrug Resistance Transporter of the Major Facilitator Superfamily, Plays an Essential Role in Spore Wall Maturation in Saccharomyces cerevisiae
- T. Felder, E. Bogengruber, S. Tenreiro, A. Ellinger, I. Sá-Correia, P. Briza
- Medicine, BiologyEukaryotic Cell
- 1 October 2002
Evidence is presented that the sporulation-specific protein Dtr1p plays an important role in spore wall synthesis by facilitating the translocation of bisformyl dityrosine through the prospore membrane.