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Plasma Homocysteine as a Risk Factor for Dementia and Alzheimer's Disease
Dementia developed in 111 subjects, including 83 given a diagnosis of Alzheimer's disease, over a median follow-up period of eight years, and plasma levels of folate and vitamins B12 and B6 increased.
Skeletal muscle cutpoints associated with elevated physical disability risk in older men and women.
Future applications of these cutpoints include the comparison of morbidity risk in older persons with normal muscle mass and those with sarcopenia, the determination and comparison of sarc Openia prevalences, and the estimation of health-care costs attributable to sarcopenian disease.
Vitamin status and intake as primary determinants of homocysteinemia in an elderly population.
A strong association between homocysteine concentration and folate, vitamin B12, and vitamin B6 status, as well as age is indicated, suggesting that a substantial majority of the cases of high homocy steine in this older population can be attributed to vitamin status.
Sarcopenia: origins and clinical relevance.
This presentation reflects on the origins of the term sarcopenia. The Greek roots of the word are sarx for flesh and penia for loss. The term actually describes important changes in body composition
The effect of folic acid fortification on plasma folate and total homocysteine concentrations.
The fortification of enriched grain products with folic acid was associated with a substantial improvement in folate status in a population of middle-aged and older adults.
Determinants of plasma total homocysteine concentration in the Framingham Offspring cohort.
This study confirmed the importance of the known determinants of fasting total homocysteine (tHcy) and suggested that other dietary and lifestyle factors, including vitamin B-6, riboflavin, alcohol, and caffeine intakes as well as smoking and hypertension, influence circulating tHcy concentrations.
A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status
The results indicate that the MTHFR C677T polymorphism influences DNA methylation status through an interaction with folate status, and is known to be solely represented in those individuals.
Prevalence of cobalamin deficiency in the Framingham elderly population.
The prevalence of cobalamin deficiency was > or = 12% in a large sample of free-living elderly Americans, and metabolites correlated best with serum cobalamina values, even when subnormal determinations were excluded.
Water, hydration, and health.
This review examines the current knowledge of water intake as it pertains to human health, including overall patterns of intake and some factors linked with intake, the complex mechanisms behind
Folate and vitamin B-12 status in relation to anemia, macrocytosis, and cognitive impairment in older Americans in the age of folic acid fortification.
In seniors with low vitamin B-12 status, high serum folate was associated with anemia and cognitive impairment when vitamin B -12 status was normal; when it was normal, however, high Serum folatewas associated with protection against cognitive impairment.