• Publications
  • Influence
Pathway involving the N155H mutation in HIV-1 integrase leads to dolutegravir resistance
Background Dolutegravir, an integrase strand-transfer inhibitor (STI), shows a high genetic barrier to resistance. Dolutegravir is reported to be effective against viruses resistant to raltegravirExpand
  • 10
  • 1
Design and Development of Biomimetic Nanovesicles Using a Microfluidic Approach.
The advancement of nanotechnology toward more sophisticated bioinspired approaches has highlighted the gap between the advantages of biomimetic and biohybrid platforms and the availability ofExpand
  • 39
Novel natural non-nucleoside inhibitors of HIV-1 reverse transcriptase identified by shape- and structure-based virtual screening techniques.
In this work we report a parallel application of both docking- and shape-based virtual screening (VS) methods, followed by Molecular Dynamics simulations (MDs), for discovering new compounds able toExpand
  • 17
The Mediterranean Diet as source of bioactive compounds with multi-targeting anti-cancer profile.
Many bioactive agents have been extracted from plants or belong to functional foods and have been considered in the treatment of serious and multifactorial diseases, such as cancer. In particular,Expand
  • 10
A Comparative Docking Strategy to Identify Polyphenolic Derivatives as Promising Antineoplastic Binders of G‐quadruplex DNA c‐myc and bcl‐2 Sequences
Polyphenols are compounds ubiquitously expressed in plants and used for their multiple healthy effects in humans as anti‐inflammatory, antimicrobial, antiviral, anticancer and immunomodulatoryExpand
  • 7
(Eco)toxicological maps: A new risk assessment method integrating traditional and in silico tools and its application in the Ledra River (Italy).
Contaminants giving rise to emerging concern like pharmaceuticals, personal care products, pesticides and Endocrine Disrupting Chemicals (EDCs) have been detected in wastewaters, as reported in theExpand
  • 8
Chromenone derivatives as a versatile scaffold with dual mode of inhibition of HIV-1 reverse transcriptase-associated Ribonuclease H function and integrase activity.
A number of compounds targeting different processes of the Human Immunodeficiency Virus type 1 (HIV-1) life cycle have been developed in the continuing fight against AIDS. Coumarin-based moleculesExpand
  • 6
Mediterranean products as promising source of multi-target agents in the treatment of metabolic syndrome.
Alteration of nutritional habits play an essential role on the risk of developing Metabolic Syndrome (MetS). Several epidemiological studies have shown that assuming diets rich of foods included inExpand
  • 16
Molecular recognition of a carboxy pyridostatin toward G‐quadruplex structures: Why does it prefer RNA?
The pyridostatin (PDS) represents the lead compound of a family of G‐quadruplex (G4) stabilizing synthetic small molecules based on a N,N′‐bis(quinolinyl)pyridine‐2,6‐dicarboxamide scaffold. ItsExpand
  • 8
A computer-assisted discovery of novel potential anti-obesity compounds as selective carbonic anhydrase VA inhibitors.
The human Carbonic anhydrases (hCA) VA and VB play a key role in ureagenesis, gluconeogenesis, lipogenesis and in the metabolism regulation, thus representing highly popular drug targets. AlbeitExpand
  • 8