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Differential clearance of neurophysin and neurohypophysial peptides from the cerebrospinal fluid in conscious guinea pigs.
TLDR
There is an effective blood/CSF barrier to neurohypophysial peptides in the guinea pig; intravenous infusions of OT or porcine NP did not raise the CSF levels of these peptides except when very high concentrations were maintained in peripheral plasma. Expand
The rebound release of growth hormone (GH) following somatostatin infusion in rats involves hypothalamic GH-releasing factor release.
TLDR
It is suggested that the rebound GH secretion that follows SS withdrawal in vivo is caused mainly by a hypothalamic release of GRF, possibly by inhibiting hypothalamic GRF release. Expand
Growth hormone secretory profiles in conscious female rats.
TLDR
It is shown for the first time that female rats switch to a rapid, highly pulsatile pattern of GH release at night, which can only be resolved by rapid blood sampling over extended periods in conscious undisturbed animals. Expand
Growth induced by pulsatile infusion of an amidated fragment of human growth hormone releasing factor in normal and GHRF-deficient rats
TLDR
It is reported here that it is possible to establish a ‘male’ type of GH secretory pattern in normal female rats by long-term pulsatile intravenous infusions of the active human G HRF fragment GHRF (1–29)NH2, and it is found that this treatment accelerates growth and increases pituitary GH content. Expand
Effects of adrenalectomy and glucocorticoids on the peptides CRF‐41, AVP and oxytocin in rat hypophysial portal blood.
TLDR
Results show that the feed‐back action of glucocorticoids is mediated by two mechanisms, and the increased release of ACTH which follows adrenolectomy is produced predominantly by an increase release of both CRF‐41 and AVP into hypophysial portal blood. Expand
Growth hormone responses to multiple injections of a fragment of human growth hormone-releasing factor in conscious male and female rats.
TLDR
Female rats can respond uniformly to repeated GRF injections, consistent with their more continuous pattern of endogenous GH secretion, compared with young conscious male and female rats to multiple i.v. injections of GH-releasing factor. Expand
Oxytocin and neurophysin in plasma and CSF during suckling in the guinea-pig.
TLDR
Cerebrospinal fluid obtained from the cisterna magna of conscious unrestrained guinea-pigs was assayed for oxytocin, vasopressin and neurophysin, concluding that the presence of these peptides in CSF reflects activity of extrapituitary terminals and that these terminals are not activated during suckling. Expand
Intravenous growth hormone: growth responses to patterned infusions in hypophysectomized rats.
TLDR
Long-term pulsatile i.v. infusions of GH mimic the endogenous secretory pattern, and are most effective when given at the physiologically appropriate pulse frequency. Expand
Release of oxytocin and prolactin in response to suckling.
TLDR
Results clearly indicate that the milk ejection reflex, with release of oxytocin, occurs in most women before the tactile stimulus of suckling, and it is important that care is taken to protect breast feeding mothers from stress not only during suckling but also immediately before nursing, when conditioned releases of Oxytocin will occur. Expand
Chronic intracerebroventricular morphine and lactation in rats: dependence and tolerance in relation to oxytocin neurones.
TLDR
Oxytocin and vasopressin contents, measured by radioimmunoassay, in the supraoptic and paraventricular nuclei and in the neurohypophysis were similar between fourteen maternal morphine‐treated, twelve vehicle‐treated and eight untreated lactating rats; thus exposure to morphine did not involve increased production and storage of oxytocin. Expand
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