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Causes and Consequences of Increased Glucose Metabolism of Cancers
In this review we examine the mechanisms (causes) underlying the increased glucose consumption observed in tumors within a teleological context (consequences). In other words, we will ask not onlyExpand
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Bicarbonate increases tumor pH and inhibits spontaneous metastases.
The external pH of solid tumors is acidic as a consequence of increased metabolism of glucose and poor perfusion. Acid pH has been shown to stimulate tumor cell invasion and metastasis in vitro andExpand
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Evaluations of extracellular pH within in vivo tumors using acidoCEST MRI
A practical, noninvasive method is needed to measure the extracellular pH (pHe) within in vivo tumors to longitudinally monitor tumor acidosis. We have optimized a biomedical imaging method, termedExpand
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Examining the relationship between diet-induced acidosis and cancer
  • I. Robey
  • Medicine
  • Nutrition & Metabolism
  • 1 August 2012
Increased cancer risk is associated with select dietary factors. Dietary lifestyles can alter systemic acid-base balance over time. Acidogenic diets, which are typically high in animal protein andExpand
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Regulation of the Warburg effect in early-passage breast cancer cells.
Malignancy in cancer is associated with aerobic glycolysis (Warburg effect) evidenced by increased trapping of [(18)F]deoxyglucose (FdG) in patients imaged by positron emission tomography (PET).Expand
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Hypoxia-inducible factor-1alpha and the glycolytic phenotype in tumors.
Metastatic tumors generally exhibit aerobic glycolysis (the Warburg effect). The advent of [18F]fluorodeoxyglucose positron emission tomography imaging, coupled with recent findings linkingExpand
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Exquisite specificity and peptide epitope recognition promiscuity, properties shared by antibodies from sharks to humans
This review considers definitions of the specificity of antibodies including the development of recent concepts of recognition polyspecificity and epitope promiscuity. Using sets of homologous andExpand
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Bicarbonate and dichloroacetate: Evaluating pH altering therapies in a mouse model for metastatic breast cancer
BackgroundThe glycolytic nature of malignant tumors contributes to high levels of extracellular acidity in the tumor microenvironment. Tumor acidity is a driving force in invasion and metastases.Expand
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Investigating Mechanisms of Alkalinization for Reducing Primary Breast Tumor Invasion
The extracellular pH (pHe) of many solid tumors is acidic as a result of glycolytic metabolism and poor perfusion. Acidity promotes invasion and enhances metastatic potential. Tumor acidity can beExpand
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Hypoxia-Inducible Factor-1 a and the Glycolytic Phenotype in Tumors 1
Metastatic tumors generally exhibit aerobic glycolysis (the Warburg effect). The advent of [F]fluorodeoxyglucose positron emission tomography imaging, coupled with recent findings linkingExpand
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