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IFN-gamma plays a critical down-regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis.
The results indicate that IFN-gamma is not essential for the generation or function of anti-MOG35-55 effector cells but does play an important role in down-regulating EAE at both the effector and induction phase of disease. Expand
Enhanced T-Cell Immunogenicity and Protective Efficacy of a Human Immunodeficiency Virus Type 1 Vaccine Regimen Consisting of Consecutive Priming with DNA and Boosting with Recombinant Fowlpox Virus
These studies suggest a safe strategy for the enhanced generation of T-cell-mediated protective immunity to HIV-1, and a consecutive immunization strategy involving priming with DNA and boosting with rFPV vaccines encoding common HIV- 1 antigens is evaluated. Expand
The prime-boost strategy: exciting prospects for improved vaccination.
Abstract Unprecedented levels of cell-mediated immunity can be stimulated by the consecutive use of DNA vaccines and attenuated poxvirus vectors encoding similar heterologous antigens. This may offerExpand
Cytokines and immunity to viral infections
Surprisingly, not only the TNFR1, but also theTNFR2, was able to mediate the antiviral effects of TNF‐α in viv, whilst the antiv viral activity observed following CD40‐CD40L interaction is a newly defined function which may involve apoptosis of infected cells. Expand
Expression of Mouse Interleukin-4 by a Recombinant Ectromelia Virus Suppresses Cytolytic Lymphocyte Responses and Overcomes Genetic Resistance to Mousepox
It is suggested that virus-encoded IL-4 not only suppresses primary antiviral cell-mediated immune responses but also can inhibit the expression of immune memory responses, similar to the disease seen when genetically sensitive mice are infected with the virulent Moscow strain. Expand
IFN-gamma is critical to the control of murine autoimmune encephalomyelitis and regulates both in the periphery and in the target tissue: a possible role for nitric oxide.
The data suggest that IFN-gamma down-regulates EAE by inducing inducible NO synthase and subsequently NO production, both by macrophages in the periphery and, by inference, microglia and astrocytes in the target tissue. Expand
The role of interleukin-6 in mucosal IgA antibody responses in vivo.
A critical role for IL-6 in vivo in the development of local IgA antibody responses is demonstrated and the effectiveness of vector-directed cytokine gene therapy is illustrated. Expand
Prime-boost immunization generates a high frequency, high-avidity CD8(+) cytotoxic T lymphocyte population.
It is found that 'prime-boost' immunization with DNA vaccines and recombinant poxvirus vectors generates high frequencies of cytotoxic T lymphocytes (CTL) that recognize target cells expressing very low levels of specific antigen. Expand
Interleukin-4 mediates down regulation of antiviral cytokine expression and cytotoxic T-lymphocyte responses and exacerbates vaccinia virus infection in vivo
It is shown that clearance of recombinant vaccinia viruses engineered to express the gene for murine IL-4 is markedly delayed in mice compared with control recombinant VV, and antiviral cytotoxic T-lymphocyte responses were profoundly suppressed throughout the course of infection with the latter. Expand
Interferon gamma is involved in the recovery of athymic nude mice from recombinant vaccinia virus/interleukin 2 infection
Athymic nude mice recover from an infection with recombinant vaccinia virus (VV) encoding murine interleukin 2 (IL-2), but treatment with a mAb to IL-2 accentuated infection. Administration of a mAbExpand