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Bombesin related peptides/receptors and their promising therapeutic roles in cancer imaging, targeting and treatment
TLDR
Recent studies support the conclusion that Bn-peptides/BnRs are well-positioned for numerous novel antitumor treatments, including interrupting autocrine-growth and the use of over-expressed receptors for imaging and targeting cytotoxic-compounds, either by direct-coupling or combined with nanoparticle-technology.
Neuropeptide G Protein-Coupled Receptors as Oncotargets
TLDR
This review will focus on how BB, NTS, VIP, and SST receptors can facilitate the early detection and treatment of cancer.
Insights into bombesin receptors and ligands: Highlighting recent advances
TLDR
There have been much progress made in the understanding of the pharmacology, cell biology and the role of (bombesin) Bn receptors and their ligands in various disease states, since the original isolation of bombesin from skin of the European frog Bombina bombina in 1970.
Insights into Effects/Risks of Chronic Hypergastrinemia and Lifelong PPI Treatment in Man Based on Studies of Patients with Zollinger–Ellison Syndrome
TLDR
The insights from studies on ZES into these controversial issues with pertinence to chronic PPI use in non-ZES patients is reviewed, primarily concentrating on data from the prospective long-term studies of ZES patients at NIH.
A possible new target in lung-cancer cells: The orphan receptor, bombesin receptor subtype-3
TLDR
The results suggest that human BRS‐3, similar to GRPR/NMBR, is frequently ectopically‐expressed by lung‐cancer cells in which, it is functional, affecting cell signaling/growth.
Characteristic of GLP-1 effects on glucose metabolism in human skeletal muscle from obese patients
TLDR
GLP-1 and exendins showed a direct normalizing action in the altered glucose uptake and metabolism in the muscle of obese subjects, which could account, at least in part, for the reported restoration of the metabolic conditions of these patients after restrictive surgery.
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