• Publications
  • Influence
Pulmonary toxicity of bleomycin analogs.
  • I. Raisfeld
  • Medicine
  • Toxicology and applied pharmacology
  • 1 December 1980
Pulmonary fibrosis develops in DBA mice within several days following a single intratracheal instillation of bleomycin. Fibrosis tends to be extensive so that lungs stained for collagen can beExpand
  • 40
  • 2
A comparison of the pulmonary toxicity produced by metal-free and copper-complexed analogs of bleomycin and phleomycin.
Abstract Previous studies from this laboratory indicated that the terminal amine groups adjacent to the thiazole rings of bleomycins are important determinants of pulmonary toxicity. The presentExpand
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  • 1
Bleomycin pulmonary toxicity: production of fibrosis by bithiazole-terminal amine and terminal amine moieties of bleomycin A2.
We have previously demonstrated that endotracheal administration of the terminal amines of several bleomycins, when administered as the free amines, produce pulmonary fibrosis of severity comparableExpand
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Role of terminal substituents in the pulmonary toxicity of bleomycins.
  • I. Raisfeld
  • Chemistry, Medicine
  • Toxicology and applied pharmacology
  • 15 March 1981
Abstract When administered to mice by the intratracheal route, bleomycin analogs produce pulmonary toxicity of varying severity. Analogs differ from each other by chemical groups (terminalExpand
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Alteration of Microsomal Biotransformation in the Liver in Cholestasis 1
Summary In cholestasis, 4 days after bile duct ligation, the activity of aminopyrine demethylase was greatly decreased, while the content of cytochrome P-450 and the activities of anilineExpand
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The effect of 3-amino-1,2,4-triazole on the phenobarbtial-induced formation of hepatic microsomal membranes.
3-Amino-1,2,4-triazole was administered to rats in combination with phenobarbital. The hepatic endoplasmic reticulum was studied chemically and by electron microscopy. The increases in cytochromeExpand
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Clinical pharmacology of drug interactions.
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Drugs and the liver: a review of metabolism and adverse reactions.
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Bleomycin-Induced Pulmonary Toxicity: A Model for the Study of Pulmonary Fibrosis
The use of bleomycin in the chemotherapy of tumors of lung and skin is limited by the development of interstitial pulmonary fibrosis(1). Older individuals, particularly those with pulmonary disease,Expand
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