Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
- R. Sherrington, E. Rogaev, P. George-Hyslop
- BiologyNature
- 29 June 1995
A minimal cosegregating region containing the AD3 gene is defined, and at least 19 different transcripts encoded within this region corresponds to a novel gene whose product is predicted to contain multiple transmembrane domains and resembles an integral membrane protein.
The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease
- E. Rogaeva, Y. Meng, P. George-Hyslop
- Biology, ChemistryNature Genetics
- 1 February 2007
It is reported here that inherited variants in the SORL1 neuronal sorting receptor are associated with late-onset Alzheimer disease, and it is shown that SOR l1 directs trafficking of APP into recycling pathways and that when SORl1 is underexpressed, APP is sorted into Aβ-generating compartments.
Conscious Expectation and Unconscious Conditioning in Analgesic, Motor, and Hormonal Placebo/Nocebo Responses
- F. Benedetti, A. Pollo, L. Lopiano, M. Lanotte, S. Vighetti, I. Rainero
- Psychology, BiologyJournal of Neuroscience
- 15 May 2003
The effects of opposing verbal suggestions on experimental ischemic arm pain in healthy volunteers and on motor performance in Parkinsonian patients are analyzed and found that verbally induced expectations of analgesia/hyperalgesia and motor improvement/worsening antagonized completely the effects of a conditioning procedure.
SQSTM1 mutations in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
- E. Rubino, I. Rainero, L. Pinessi
- Biology, MedicineNeurology
- 9 October 2012
Evaluated the frequency of SQSTM1 mutations in a dataset of unrelated patients with FTLD or ALS, in comparison with healthy controls and patients with Paget disease of bone (PDB), and suggested a pathogenetic role for these mutations.
Frontotemporal dementia and its subtypes: a genome-wide association study
- R. Ferrari, D. Hernandez, P. Momeni
- Biology, PsychologyLancet Neurology
- 1 July 2014
Conduction velocity along human muscle fibers in situ
- W. Troni, R. Cantello, I. Rainero
- BiologyNeurology
- 1 November 1983
As direct muscle stimulation is feasible and safe, propagation velocity along single fibers can be determined in situ over a long distance and the distally evoked potentials show a linear relationship between latency and distance.
Loss of expectation-related mechanisms in Alzheimer’s disease makes analgesic therapies less effective
- F. Benedetti, C. Arduino, G. Asteggiano
- Psychology, MedicinePain
- 1 March 2006
Voxel‐Based Morphometry Reveals Gray Matter Abnormalities in Migraine
- W. Valfrè, I. Rainero, M. Bergui, L. Pinessi
- Medicine, PsychologyHeadache
- 20 December 2007
This work has shown that migraine may be associated with subtle brain lesions, and has the potential to improve the diagnosis and treatment of migraine patients with prior history of migraine.
Open versus hidden medical treatments: The patient's knowledge about a therapy affects the therapy outcome.
- F. Benedetti, Giuliano Maggi, A. Pollo
- Medicine, Psychology
- 1 June 2003
To do this, the authors performed hidden medical treatments and compared these with the open ones, showing that the hidden administrations of pharmacological and nonpharmacological therapies are less effective than the open one.
Behavioral and Psychological Effects of Coronavirus Disease-19 Quarantine in Patients With Dementia
- A. Cagnin, R. D. Di Lorenzo, Erica Alberto Andrea Fausto Paola Francesca Gianfranco R Gallo Grassini Marcinnò Roveta De Martino Frangipa
- Medicine, PsychologyFrontiers in Psychiatry
- 9 September 2020
Quarantine induces a rapid increase of BPSD in approximately 60% of patients and stress-related symptoms in two-thirds of caregivers and were associated with increased patients’ neuropsychiatric burden (p<0.0001); health services need to plan a post-pandemic strategy.
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